ABSTRACT
El carcinoma de células grandes de pulmón con inmunofenotipo nulo (LCC-NI) constituye una entidad diagnóstica que hoy en día es especialmente infrecuente ya que no cuenta con ningún tipo de diferenciación celular o alteraciones moleculares propias. Representa un reto diagnóstico excepcional, el cual solo es posible realizar por exclusión contando con la resección quirúrgica, estudios de inmunohistoquímica y moleculares adecuados. Presentamos el caso de un varón de 69años de edad, con antecedente de alto índice tabáquico, que debuta con dolor pleurítico y tumor en el lóbulo pulmonar superior derecho, el cual se retira mediante lobectomía. A la evaluación patológica muestra una morfología de células grandes sin ningún inmunofenotipo, alteraciones moleculares o genómicas mediante estudios de secuenciación de siguiente generación (NGS), diagnosticándose como un LCC-NI.(AU)
Large cell carcinoma of the lung with null-immunophenotype (LCC-NI) is a diagnostic entity that is especially uncommon now as it does not have any type of cell differentiation or its own molecular alterations. It presents an exceptional diagnostic challenge; indeed, the diagnosis is only possible with complete surgical excision and adequate immunohistochemical and molecular studies. We report the case of a 69-year-old male, with a history of long-term smoking who presented with pleuritic pain. A tumor in the upper lobe of the right lung was detected and removed by lobectomy. Histopathology revealed a neoplasm with large cell morphology without any specific immunophenotype, molecular or genomic rearrangements through next-generation sequencing (NGS) studies, which was diagnosed as LCC-NI.(AU)
Subject(s)
Humans , Carcinoma, Large Cell , Carcinoma, Large Cell/diagnosis , Immunophenotyping , Thoracic Neoplasms , Inpatients , Physical ExaminationABSTRACT
Large cell carcinoma of the lung with null-immunophenotype (LCC-NI) is a diagnostic entity that is especially uncommon now as it does not have any type of cell differentiation or its own molecular alterations. It presents an exceptional diagnostic challenge; indeed, the diagnosis is only possible with complete surgical excision and adequate immunohistochemical and molecular studies. We report the case of a 69-year-old male, with a history of long-term smoking who presented with pleuritic pain. A tumor in the upper lobe of the right lung was detected and removed by lobectomy. Histopathology revealed a neoplasm with large cell morphology without any specific immunophenotype, molecular or genomic rearrangements through next-generation sequencing (NGS) studies, which was diagnosed as LCC-NI.
