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1.
HIV AIDS (Auckl) ; 11: 155-164, 2019.
Article in English | MEDLINE | ID: mdl-31413642

ABSTRACT

BACKGROUND: Puerto Rico is among the areas with the highest estimated rates of people living with HIV in the United States. Despite the epidemiologic data available, there is limited real-world information that can help understand the comorbidities of people with HIV. In this study, we describe common comorbidities among adults with HIV attending treatment clinics in Puerto Rico. METHODS: An exploratory, retrospective, cross-sectional study was conducted at five HIV clinics in Puerto Rico. A random sample of medical records was reviewed. Descriptive statistics were used to summarize patient demographics, morbidity, and clinical characteristics. Multivariate analyses were conducted to explore comorbidities by age and sex. RESULTS: A total of 250 (179 men; 71 women) medical records were reviewed. Participants' mean age was 47.9 years and on average they had been living with HIV for 9 years. Most (97.6%) had at least one comorbidity. The most common comorbidities were dyslipidemia and hypertension. Men were more likely to have been diagnosed with alcohol misuse while women were more likely to have been diagnosed with obesity, human papillomavirus (HPV), hypothyroidism, and osteoporosis. Participants younger than 50 years of age were more likely to have history of alcohol misuse while older individuals (50 years and old) were more likely to have been diagnosed with dyslipidemia, hypertension, and diabetes. Adjusting by sex and age, women were more likely to have been diagnosed with obesity and depression and those older than 50 years were more likely to have had a diagnosis of dyslipidemia, hypertension, HPV, and diabetes. CONCLUSIONS: This is one of the few studies assessing comorbidities among adults with HIV in Puerto Rico, among Latino/Hispanics within the United States, and Latin America. Consistent with other studies, cardiovascular diseases are common among adults with HIV in Puerto Rico. Findings support the need for awareness and real-world evidence about comorbidities among people with HIV when implementing screenings and prescribing drugs.

2.
Arch. Hosp. Vargas ; 39(3/4): 165-70, jul.-dic. 1997. tab
Article in Spanish | LILACS | ID: lil-213214

ABSTRACT

Se realizó un estudio clínico prospectivo no comparativo evaluando la eficacia y tolerancia de Cefoperazona-Sulbactam (CFZ-SBT) como monoterapia en infecciones intraabdominales que no fueran de origen traumático penetrante. Se incluyeron 30 pacientes que consultaron al Hospital Vargas de Caracas de julio 1995 a octubre y en quienes se diagnosticó infección intraabdominal que requería tanto de intervención quirúrgica como de antibioticoterapia. Se tomaron hemocultivos y cultivos de fluidos de la fuente de infección, determinando la sensibilidad in vitro de los gérmenes aislados. Los pacientes fueron evaluados desde el punto de vista clínico y de laboratorio antes, durante y después de finalizar el tratamiento, de 3 a 9 grs., endovenosos de CPZ-SBT fueron administrados diariamente de 7 a 14 días, de acuerdo a la severidad de la infección. El 73,3 por ciento de los gérmenes patógenos causantes de la infección intraabdominal fueron Gram negativo aerobios y anaerobios facultativos. Todos los gérmenes aislados de las diferentes fuentes de infección fueron sensibles in vitro a CPZ-SBT. Se obtuvo un 68,4 por ciento de erradicación y 31,6 por ciento de superinfección. Clinicamente, se reportó 80 por ciento de curación y 20 por ciento de fracaso. No hubo efectos adversos atribuibles al uso del antibiótico


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Abdomen/pathology , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , Cefoperazone/therapeutic use , Drug Resistance, Microbial , Infections , Sulbactam/therapeutic use
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