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1.
J Invasive Cardiol ; 33(5): E405, 2021 05.
Article in English | MEDLINE | ID: mdl-33932289

ABSTRACT

We describe what could be a bailout strategy in the event of (1) failure to reach the distal true lumen, (2) slight improvement in the distal flow, but allowing clinical resolution of STEMI, or (3) a situation not suited to surgery. The "prick-and-wait" technique presented in this case led to a complete recovery.


Subject(s)
Angioplasty, Balloon, Coronary , Coronary Vessel Anomalies , Vascular Diseases , Coronary Angiography , Dissection , Humans , Vascular Diseases/diagnosis , Vascular Diseases/surgery
2.
ESC Heart Fail ; 8(3): 2316-2319, 2021 06.
Article in English | MEDLINE | ID: mdl-33792203

ABSTRACT

A 72-year-old man daily suffered from a refractory angina consecutive to a diffuse coronary artery disease despite optimal medical management. Revascularization could not be performed because of a severe thrombopenia. He was referred to our outpatient cardiac rehabilitation programme where he was candidate for 20 sessions, three times a week, of high-intensity aerobic interval training involving brief episodes of regressive myocardial ischaemia. After 7 weeks, exercise capacity (+28.5%), VO2 peak (35.7%), and ischaemic threshold increased while clinical status and quality of life improved. No adverse effect was reported. Aerobic interval training with myocardial ischaemia might be a therapeutic alternative in refractory angina.


Subject(s)
Cardiac Rehabilitation , Coronary Artery Disease , Myocardial Ischemia , Aged , Angina Pectoris/diagnosis , Angina Pectoris/therapy , Humans , Male , Myocardial Ischemia/complications , Quality of Life
3.
J Card Fail ; 26(12): 1067-1074, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32942010

ABSTRACT

BACKGROUND: Coronary angiography (CA) is usually performed in patients with reduced left ventricular ejection fraction (LVEF) to search ischemic cardiomyopathy. Our aim was to examine the agreement between CA and cardiovascular magnetic resonance (CMR) imaging among a cohort of patients with unexplained reduced LVEF, and estimate what would have been the consequences of using CMR imaging as the first-line examination. METHODS: Three hundred five patients with unexplained reduced LVEF of ≤45% who underwent both CA and CMR imaging were retrospectively registered. Patients were classified as CMR+ or CMR- according to presence or absence of myocardial ischemic scar, and classified CA+ or CA- according to presence or absence of significant coronary artery disease. RESULTS: CMR+ (n = 89) included all 54 CA+ patients, except 2 with distal coronary artery disease in whom no revascularization was proposed. Among the 247 CA- patients, 15% were CMR+. CMR imaging had 96% sensitivity, 85% specificity, 99% negative predictive value, and 58% positive predictive value for detecting CA+ patients. Revascularization was performed in 6.5% of the patients (all CMR+). Performing CA only for CMR+ patients would have decreased the number of CAs by 71%. CONCLUSIONS: In reduced LVEF, performing CA only in CMR+ patients may significantly decrease the number of unnecessary CAs performed, without missing any patients requiring revascularization.


Subject(s)
Heart Failure , Ventricular Dysfunction, Left , Coronary Angiography , Humans , Magnetic Resonance Imaging , Magnetic Resonance Imaging, Cine , Magnetic Resonance Spectroscopy , Pilot Projects , Predictive Value of Tests , Retrospective Studies , Stroke Volume , Ventricular Dysfunction, Left/diagnostic imaging , Ventricular Function, Left
4.
Atherosclerosis ; 293: 86-91, 2020 01.
Article in English | MEDLINE | ID: mdl-31877397

ABSTRACT

BACKGROUND AND AIMS: Genetic partial lipodystrophies are rare heterogeneous disorders characterized by abnormalities of fat distribution and associated metabolic complications including a predisposition for atherosclerotic cardiovascular disease. We hypothesized that the milder forms of these diseases might be underdiagnosed and might result in early acute coronary syndrome (ACS) as the first sign of the pathology. METHODS: We performed targeted sequencing on a panel of 8 genes involved in genetic lipodystrophy for 62 patients with premature ACS, and selected heterozygous missense variations with low frequency. To confirm those results, we analyzed a second independent group of 60 additional patients through Sanger sequencing, and compared to a control group of 120 healthy patients. RESULTS: In the first cohort, only PLIN1 exhibited variants in more than 1 patient. In PLIN1, 3 different variants were found in 6 patients. We then analyzed PLIN1 sequence in the second cohort with premature ACS and found 2 other patients. Altogether, 8 patients were carriers of 4 different mutations in PLIN1. The variant frequencies in the total cohort of 122 patients were compared to frequencies observed in a local control cohort and in 2 different public databases showing a significant difference between patient vs control group frequencies for two mutations out of 4 (c.245C > T p = 10-4; c.839G > A p = 0.014). DISCUSSION: This is the first study that identifies a high frequency of potential pathogenic mutations in PLIN1 related to early onset ACS. These findings could contribute to the prevention and care of precocious ACS in families carrying those mutations.


Subject(s)
Acute Coronary Syndrome/genetics , DNA/genetics , Genetic Predisposition to Disease , Mutation , Perilipin-1/genetics , Acute Coronary Syndrome/metabolism , Adult , DNA Mutational Analysis , Female , Follow-Up Studies , Genotype , Humans , Male , Perilipin-1/metabolism , Prevalence , Prospective Studies , Recurrence
9.
Ann Thorac Surg ; 103(1): e9-e10, 2017 Jan.
Article in English | MEDLINE | ID: mdl-28007287

ABSTRACT

Management of heparin-induced thrombocytopenia (HIT) entails cessation of heparin and initiation of a nonheparin parenteral anticoagulant such as danaparoid. Danaparoid cross-reactivity with HIT antibodies is an uncommon complication of treatment of HIT. We report the case of confirmed HIT and in vivo cross-reactivity with danaparoid, complicating severe sepsis due to an infectious endocarditis treated by cardiac surgery.


Subject(s)
Cardiac Surgical Procedures , Chondroitin Sulfates/immunology , Dermatan Sulfate/immunology , Heart Valve Diseases/surgery , Heparin/immunology , Heparitin Sulfate/immunology , Thrombocytopenia/complications , Anticoagulants/immunology , Anticoagulants/therapeutic use , Chondroitin Sulfates/therapeutic use , Cross Reactions , Dermatan Sulfate/therapeutic use , Heparin/adverse effects , Heparitin Sulfate/therapeutic use , Humans , Male , Middle Aged , Thrombocytopenia/immunology
10.
J Electrocardiol ; 48(4): 729-33, 2015.
Article in English | MEDLINE | ID: mdl-25796100

ABSTRACT

Pulmonary vein isolation (PVI) using cryoballoon (CB) technique and cavotricuspid isthmus (CTI) ablation using radiofrequency (RF) are established interventions for drug-resistant atrial fibrillation (AF) and typical atrial flutter (AFL). Twelve patients with a mean age of 62 ± 12 years underwent simultaneous delivery of RF energy at the CTI during CB applications at the PV ostia. Pulmonary vein isolation was achieved in all PVs and sustained bidirectional CTI conduction block obtained in all patients. The reported ablation protocol of combined paroxysmal AF and typical AFL did not result in prolongation of the procedure duration or in prolonged radiation exposure when compared to CB-PVI alone. No interferences between both ablation energy systems were observed. These preliminary results suggest that combined paroxysmal AF and typical AFL can be successfully and safely ablated using hybrid energy sources with simultaneous CTI ablation using RF during CB applications at the PV ostia.


Subject(s)
Atrial Fibrillation/surgery , Atrial Flutter/surgery , Catheter Ablation/methods , Cryosurgery/methods , Heart Conduction System/surgery , Pulmonary Veins/surgery , Adult , Aged , Aged, 80 and over , Atrial Fibrillation/complications , Atrial Fibrillation/diagnosis , Atrial Flutter/complications , Atrial Flutter/diagnosis , Combined Modality Therapy/methods , Female , Humans , Male , Middle Aged , Treatment Outcome , Tricuspid Valve/surgery
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