ABSTRACT
The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.
Subject(s)
Inflammatory Bowel Diseases/genetics , Isoenzymes/genetics , Protein Tyrosine Phosphatases/genetics , Proto-Oncogene Proteins , Sex Characteristics , Signal Transduction/genetics , Colitis, Ulcerative/enzymology , Colitis, Ulcerative/genetics , Crohn Disease/enzymology , Crohn Disease/genetics , Female , Genetic Predisposition to Disease , Genomic Imprinting , Genotype , Humans , Infant, Newborn , Inflammatory Bowel Diseases/enzymology , Inflammatory Bowel Diseases/epidemiology , Male , Phenotype , Phosphorylation , Protein Processing, Post-Translational/genetics , Receptors, Growth Factor/physiology , Rome/epidemiologySubject(s)
Anti-Bacterial Agents/administration & dosage , Burns, Chemical/drug therapy , Caustics/adverse effects , Cimetidine/administration & dosage , Cortisone/administration & dosage , Esophagitis/chemically induced , Gastritis/chemically induced , Guanidines/administration & dosage , Hydrochloric Acid/adverse effects , Adult , Drug Therapy, Combination , Esophagitis/drug therapy , Female , Gastritis/drug therapy , Humans , Suicide, Attempted , Time FactorsSubject(s)
Gastrectomy , Peptic Ulcer/drug therapy , Adult , Analgesics/therapeutic use , Antacids/therapeutic use , Female , Gastrins/antagonists & inhibitors , Humans , Hypnotics and Sedatives/therapeutic use , Male , Parasympatholytics/therapeutic use , Peptic Ulcer/diet therapy , Peptic Ulcer/surgery , Postoperative Complications , Recurrence , Tranquilizing Agents/therapeutic useABSTRACT
The history of intensive care in gastroenterology is briefly discussed. The insertion of intensive care units in the hospital scene is also examined and illustrative examples of emergency cases treated in recent years at the Rome United Hospitals gastroenterology division are presented. It is felt that centres tailored to hospital dimensions should be formed, though their cost is likely to prove a bar to their early institution. Intensive care can, it is urged, be furnished by specialist departments, provided they manage to find a new dimension in keeping with the more difficult tasks involved.
