[Cytogenetic effect of protecting the bone marrow of mice and monkeys by using measured hypoxia in the action of low ionizing radiation doses]. / Tsitogeneticheskii éffekt zashchity kostnogo mozga myshei i obez'ian s pomoshch'iu dozirovannoi gipoksii pri deistvii malykh doz ioniziruiushchei radiatsii.

The statistical reliable cytogenetic effect on bone marrow cells of mice and monkeys was achieved by means of dosage hypoxic hypoxia produced by breathing of gas hypoxic mixture containing 10% oxygen and 90% nitrogen (GHM-10). The effect was detested after total irradiation of mice and local irradiation of monkeys. The dose of irradiation was 100 rad (10 R/min and 17.4 R/min).

[Differences in the efficacy of gutimine alpha-ketoglutarate in the hypoxic and motor forms of hypoxia]. / O razlichii éffektivnosti al'fa-ketogliutarata gutimina pri gipoksicheskoi i dvigatel'noi formakh gipoksii.

When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.