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1.
Clin Exp Dermatol ; 35(6): 624-6, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20236286

ABSTRACT

Isotretinoin has revolutionized the treatment of acne by improving the cosmetic outcome and decreasing the psychological damage. However, use of isotretinoin is associated with significant side-effects such as mucocutaneous involvement, dyslipidaemia and liver dysfunction, as indicated by increases in liver enzymes. The responsible enzyme for homocysteine metabolism, cystathionine-beta-synthase, might also be affected by isotretinoin-induced liver dysfunction, which leads to hyperhomocysteinaemia, an independent risk factor for thrombovascular diseases. The aim of this study was to evaluate homocysteine levels and the responsible vitamins for its metabolism in patients with moderate to severe acne vulgaris on isotretinoin treatment, before and after treatment. We found increased level of homocysteine in patients after 2 months of taking isotretinoin. Our findings suggest that isotretinoin may increase the risk of cardiovascular disorders by causing hyperhomocysteinaemia.


Subject(s)
Acne Vulgaris/drug therapy , Dermatologic Agents/adverse effects , Homocysteine/blood , Isotretinoin/adverse effects , Acne Vulgaris/blood , Adolescent , Female , Humans , Hyperhomocysteinemia/chemically induced , Liver Function Tests , Male , Risk Factors , Treatment Outcome , Young Adult
2.
J Eur Acad Dermatol Venereol ; 23(8): 948-50, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19453814

ABSTRACT

AIM: The intent of our study was to determine the efficacy of oral naltrexone, an opioid antagonist, in the treatment of pruritus in patients with chronic eczema. METHODS: This double-blind, placebo-controlled study recruited 38 patients with eczema complaining from pruritus. Pruritus scores were evaluated. Patients were given placebo (n = 20) or naltrexone 50 mg (n = 18) for 2 weeks period. During the study, pruritus scores based on visual analogue scale system (VAS) were assessed three times: at the start of study, after 1 week, and after 2 weeks. RESULTS: In both groups, decreased VAS scores were observed, but naltrexone showed to be significantly more effective than placebo in decreasing VAS score after 1 week (P < 0.005) and 2 weeks (P < 0.001). CONCLUSION: Naltrexone is more effective than placebo in the treatment of pruritus in patient with eczema. Naltrexone might be considered as an adjunct treatment in the treatment of pruritus. However, further studies in this aspect are highly fostered.


Subject(s)
Dermatitis, Atopic/complications , Naltrexone/administration & dosage , Naltrexone/therapeutic use , Narcotic Antagonists/administration & dosage , Narcotic Antagonists/therapeutic use , Pruritus/drug therapy , Pruritus/etiology , Administration, Oral , Adult , Aged , Aged, 80 and over , Dizziness/chemically induced , Dose-Response Relationship, Drug , Double-Blind Method , Female , Headache/chemically induced , Humans , Male , Middle Aged , Naltrexone/adverse effects , Narcotic Antagonists/adverse effects , Nausea/chemically induced , Pain Measurement , Treatment Outcome
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