Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
1.
BMJ Open ; 14(3): e080620, 2024 Mar 19.
Article in English | MEDLINE | ID: mdl-38508619

ABSTRACT

INTRODUCTION: Satisfactory management of acute pain remains a major medical challenge despite the availability of multiple therapeutic options including the fixed-dose combination (FDC) drugs. Tramadol and dexketoprofen trometamol (TRAM/DKP) 75/25 mg FDC was launched in 2018 in Asia and is widely used in the management of moderate to severe acute pain. There are limited data on its effectiveness and safety in Asian patients, and therefore, a need to better understand its usage patterns in clinical practice. We aim to understand the usage pattern of TRAM/DKP FDC, its effectiveness and tolerability in patients with moderate to severe acute pain in Asia. METHODS AND ANALYSIS: REKOVER is a phase-IV, multicountry, multicentre, prospective, real-world observational study. A total of 750 postsurgical and non-surgical patients (male and female, aged 18-80 years) will be recruited from 13 tertiary-care hospitals (15 sites) in Singapore, Thailand, the Philippines and Malaysia. All patients prescribed with TRAM/DKP FDC and willing to participate in the study will be enrolled. The recruitment duration for each site will be 6 months. The severity of pain will be collected using Numeric Pain Rating Scale through the treatment period from day 1 to day 5, while satisfaction with the treatment will be evaluated using Patient Global Evaluation Scale at the end of treatment. Any adverse event reported during the study duration will be recorded for safety analysis (up to day 6). The study data will be entered into the ClaimIt portal and mobile application (app) (ObvioHealth, USA). All the inpatient data will be entered into the portal by the study site and for outpatient it will be done by patients through an app. ETHICS AND DISSEMINATION: The study has been approved by the local ethics committee from each study sites in Singapore, Thailand, the Philippines and Malaysia. Findings will be disseminated through local and global conference presentations, publications in peer-reviewed scientific journals and continuing medical education.


Subject(s)
Acute Pain , Ketoprofen/analogs & derivatives , Tramadol , Tromethamine , Humans , Male , Female , Tramadol/therapeutic use , Acute Pain/drug therapy , Prospective Studies , Pain, Postoperative/drug therapy , Double-Blind Method , Registries , Thailand , Observational Studies as Topic , Drug Combinations
2.
Clin Case Rep ; 9(3): 1083-1091, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33768787

ABSTRACT

A matrix therapy agent marketed as CACIPLIQ20® showed marked improvement in the healing rate of hand infections, including functional recovery. It can be used at both earlier and later stages to promote faster healing and prevent an adverse outcome.

3.
Clin Case Rep ; 7(4): 619-625, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30997049

ABSTRACT

CACIPLIQ20® significantly improved the outcomes of severe burn injuries of the hand. Healing was accelerated, with little or no scarring, allowing for greater mobility over the joints and maintained suppleness. Functional recovery was achieved in all cases.

4.
Gait Posture ; 48: 152-158, 2016 07.
Article in English | MEDLINE | ID: mdl-27318454

ABSTRACT

This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty-two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post-operation using three-dimensional motion analysis system. Five separate components, including knee range of motion (ROM), vertical ground reaction force (VGRF), their symmetries and knee extension moment were evaluated. One way and repeated measure multivariate analysis of variance (MANOVA) were used to analyze the knee ROMs. The VGRF and extension moment were tested using repeated measure ANOVA and independent sample t-test. Findings indicated significant alterations in all measured components between patients' Test 1 and control group. Repeated measure analysis revealed significant effect for time in components of knee angular and VGRF (P<0.001), their symmetry index (P=0.03) and knee extension moment (P=0.045). Univariate outcomes demonstrated significant improvement in the injured limb's stance and swing (P<0.001), and single-stance (P=0.005) ROMs over time. Symmetry indexes of stance and swing ROM, and VGRF reduced significantly by 26.3% (P=0.001), 17.9% (P<0.001), and 31.9% (P=0.03) respectively. After three months, symmetry indexes of single-stance ROM and VGRF along with operated knee extension moment were the only variables which showed significant differences with control group. The rehabilitation program allowed national athletes to restore the operated limb's gait parameters except knee extension moment by 12-13 weeks post-reconstruction; however, more time is required to normalize single-stance ROM and VGRF asymmetries.


Subject(s)
Anterior Cruciate Ligament Injuries/surgery , Gait , Analysis of Variance , Anterior Cruciate Ligament Injuries/rehabilitation , Anterior Cruciate Ligament Reconstruction , Athletic Injuries/rehabilitation , Athletic Injuries/surgery , Biomechanical Phenomena , Female , Humans , Male , Postoperative Period , Range of Motion, Articular , Recovery of Function , Young Adult
5.
J Biosci Bioeng ; 118(2): 231-4, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24598302

ABSTRACT

We evaluated bridging of 15 mm nerve gap in rat sciatic nerve injury model with muscle-stuffed vein seeded with olfactory ensheathing cells as a substitute for nerve autograft. Neurophysiological recovery, as assessed by electrophysiological analysis was faster in the constructed biological nerve conduit compared to that of autograft.


Subject(s)
Nerve Regeneration , Sciatic Nerve/physiopathology , Tissue Engineering , Animals , Female , Muscle, Skeletal/pathology , Neural Conduction , Olfactory Nerve/pathology , Peripheral Nerve Injuries/therapy , Rats, Sprague-Dawley , Regenerative Medicine , Sciatic Nerve/pathology , Veins/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...