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1.
Br J Cancer ; 90(5): 1003-10, 2004 Mar 08.
Article in English | MEDLINE | ID: mdl-14997197

ABSTRACT

Intravenous fluorouracil and leucovorin is the standard adjuvant treatment for stage III colon cancer. However, oral adjuvant chemotherapy is attractive because it has low toxicity and greater convenience. We investigated the benefits of oral protein-bound polysaccharide K (PSK) with tegafur/uracil (UFT) as an adjuvant in stage II and III colorectal cancer. Patients were assigned to groups that received either 3 g PSK plus 300 mg UFT, or 300 mg UFT alone orally each day for a 2-year period following intravenous mitomycin C. Of 207 registered patients, 205 with stage II (n=123) or III (n=82) were analysed. The 5-year disease-free survival was 73.0% (95% CI 65.6-80.4%) with PSK (n=137) and 58.8% (95% CI 47.1-70.5%) in the controls (n=68) (P=0.016). Polysaccharide K reduced the recurrence by 43.6% (95% CI 4.5-66.7%) and mortality by 40.2% (95% CI -12.5 to 68.3%). The 5-year survival was 81.8% (95% CI 75.3-88.2%) in the PSK group and 72.1% (95% CI 61.4-82.7%) in the control group (P=0.056). In stage III patients, disease-free and overall survivals in patients receiving PSK were increased significantly: 60.0% (95% CI 47.1-72.9%) and 74.6% (95% CI 63.0-86.1%) in the PSK group as compared with 32.1% (95% CI 14.8-49.4%) and 46.4% (95% CI 28.0-64.9%) in the controls (P=0.002 and 0.003, respectively). Polysaccharide K prevented recurrence, particularly lung metastases (P=0.02; odds ratio 0.27; 95% CI 0.09-0.77). In the models, the presence of regional metastases (relative risk, 2.973; 95% CI 1.712-5.165; P<0.001), omission of PSK (relative risk, 2.106; 95% CI 1.221-3.633; P=0.007), and higher primary tumour (relative risk, 4.398; 95% CI 1.017-19.014; P=0.047) were each significant indicators of recurrence. Adverse effects were mild and compliance was good. Oral PSK with UFT reduced recurrence in stage II and III colorectal cancer, and increased survival in stage III.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colorectal Neoplasms/drug therapy , Administration, Oral , Adult , Aged , Chemotherapy, Adjuvant , Colorectal Neoplasms/secondary , Female , Humans , Male , Middle Aged , Neoplasm Invasiveness/pathology , Neoplasm Recurrence, Local/drug therapy , Neoplasm Recurrence, Local/pathology , Neoplasm Staging , Neoplasm, Residual/drug therapy , Neoplasm, Residual/pathology , Neoplasms, Second Primary/etiology , Proteoglycans/administration & dosage , Risk Factors , Survival Rate , Tegafur/administration & dosage , Treatment Outcome
2.
Kyobu Geka ; 53(13): 1133-6, 2000 Dec.
Article in Japanese | MEDLINE | ID: mdl-11127562

ABSTRACT

A 54-year-old woman, who had underwent an adjuvant radiotherapy following the modified radical mastectomy in the left primary breast cancer in June 1988. She underwent second surgery and adjuvant radiotherapy (electronic radiotherapy) for recurrent breast cancer in the major pectoral muscle and received chemoimmunotherapy in May 1989. In May 1996 she complained of two ulcers of the chest wall. The ulcer biopsy findings was squamous cell carcinoma, and we diagnosed she fell the radiation-induced skin cancer. She underwent chest wall resection and reconstruction with vertical rectal abdominal musculocutaneous flap (VRAM). However two months later her chest wall resection, she again got the recurrent squamous cell carcinoma in the right axillary lymph nodes and left pleura. The third radiotherapy and the chemotherapy with pepleomycin were uneffective on her recurrent cancer. And she died in March 1997.


Subject(s)
Breast Neoplasms/therapy , Carcinoma, Ductal, Breast/therapy , Carcinoma, Squamous Cell/etiology , Mastectomy, Radical , Neoplasms, Radiation-Induced , Thoracic Neoplasms/etiology , Thorax , Fatal Outcome , Female , Humans , Middle Aged , Radiotherapy, Adjuvant/adverse effects , Time Factors
3.
Jpn J Clin Oncol ; 30(1): 43-5, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10770570

ABSTRACT

Following a simple cholecystectomy, a 63-year-old woman with gallstones was histologically diagnosed as having minute squamous cell carcinoma of the gallbladder. A laparotomy revealed a small, firm nodule that appeared to be an adenoma, which was palpated in the fundus of the gallbladder. The resected gallbladder contained 37 small stones and a small and firm mass (0.4 x 0.4 x 0.3 cm in size) on the mucosal side. Histologically, a pure type of well-differentiated squamous cell carcinoma of the gallbladder was diagnosed. To our knowledge, this is the first case of a minute and pure type of squamous cell carcinoma in the gallbladder. This case may have implications for the histogenesis of squamous cell carcinoma of the gallbladder.


Subject(s)
Carcinoma, Squamous Cell/diagnosis , Gallbladder Neoplasms/diagnosis , Adenoma/diagnosis , Carcinoma, Squamous Cell/pathology , Cholecystectomy , Cholelithiasis/surgery , Diagnosis, Differential , Epithelium/pathology , Female , Follow-Up Studies , Gallbladder/pathology , Gallbladder Neoplasms/pathology , Humans , Laparotomy , Middle Aged , Mucous Membrane/pathology
4.
J Comput Assist Tomogr ; 23(1): 69-73, 1999.
Article in English | MEDLINE | ID: mdl-10050811

ABSTRACT

We present four cases of common bile duct carcinoma in which both angiographic helical CT (angio-HCT) and pancreatoduodenectomy were done in the 3 years since 1995. Angio-HCT was performed with direct infusion of the contrast medium through the gastroduodenal artery inserted on angiography. Angio-HCT displayed the tumors as lower density areas in contrast to the strong enhancement of the circumferential nontumorous areas, including the pancreas and duodenum.


Subject(s)
Adenocarcinoma/diagnostic imaging , Angiography , Common Bile Duct Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Aged , Common Bile Duct Neoplasms/pathology , Common Bile Duct Neoplasms/surgery , Contrast Media/administration & dosage , Humans , Injections, Intra-Arterial , Male , Pancreaticoduodenectomy
5.
Gan To Kagaku Ryoho ; 25(5): 739-42, 1998 Apr.
Article in Japanese | MEDLINE | ID: mdl-9571973

ABSTRACT

A 59-year-old female complaining of breast tumor with suppurative discharge was diagnosed as having advanced breast cancer (T4cN3M1-StIV), with giant liver metastasis. Seven courses of combined chemoendocrine therapy (CTF + MPA) were used. Following the chemoendocrine therapy, primary tumor, lung, pleural, supraclavicular and parasternal metastasis disappeared, and the liver metastasis was obviously diminished. These effects continued for 1 year 7 months. Although CTF + MPA chemoendocrine therapy is widely used with advanced or recurrent breast cancer, a clearly effective case has almost never been reported. The reason for the remarkable effect in this case was the consistent immunity to breast cancer.


Subject(s)
Antineoplastic Agents, Hormonal/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Carcinoma, Ductal, Breast/drug therapy , Medroxyprogesterone Acetate/administration & dosage , Bone Neoplasms/secondary , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/secondary , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Doxorubicin/analogs & derivatives , Drug Administration Schedule , Female , Fluorouracil/administration & dosage , Humans , Liver Neoplasms/secondary , Lung Neoplasms/secondary , Lymphatic Metastasis , Middle Aged
6.
Anticancer Res ; 17(3C): 2313-8, 1997.
Article in English | MEDLINE | ID: mdl-9216708

ABSTRACT

BACKGROUND: The purpose of the study was to verify whether OK-432 in combination with 5'-DFUR induced thymidine phosphorylase (TdR Pase) and cytokines in gastric cancer patients as well as in vitro. MATERIALS AND METHODS: Fifty patients with invasive gastric cancer were randomly assigned, upon admission using by a closed-envelope technique, to either a group receiving 5'DFUR or OK-432 alone, to a group receiving both 5'DFUR and OK-432, or to a non- treated group up. Surgical specimens of the tumor and normal tissues were taken soon after gastrectomy to evaluate TdR Pase activity, IL-1 alpha and TNF-production. RESULTS: TdR Pase activities were several times higher in tumor than in normal tissues. In normal tissues, TdR Pase activities in the 5'-DFUR + OK-432 group were significantly higher than in the OK-432 group. TdR Pase activity in tumors, however, showed no significant difference between treated group. In the 5'-DFUR + OK-432 group, the level of IL-1 alpha production in tumor was significantly higher compared to the control group. In the 5'-DFUR + OK-432 group, the level of TNF alpha production in tumor was significantly higher than in normal tissue. TNF alpha production in tumor showed no significant difference in each treated group compared to the control. There was a significant correlation between TdR Pase activity and IL-1 alpha production levels in tumor. CONCLUSIONS: TdR Pase was induced by IL-1 alpha in tumor tissues of gastric cancer patients. OK-432 in combination with 5'-DFUR, however, did not induce TNF alpha and IL-1 alpha, and increase TdR Pase activity in gastric cancer tumors.


Subject(s)
Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cytokines/biosynthesis , Floxuridine/therapeutic use , Picibanil/therapeutic use , Stomach Neoplasms/drug therapy , Thymidine Phosphorylase/biosynthesis , Antineoplastic Agents/administration & dosage , Enzyme Induction , Floxuridine/administration & dosage , Gastrectomy , Gene Expression , Humans , Interleukin-1/biosynthesis , Neoplasm Invasiveness , Neoplasm Staging , Picibanil/administration & dosage , Stomach/pathology , Stomach Neoplasms/pathology , Stomach Neoplasms/physiopathology , Stomach Neoplasms/surgery , Tumor Necrosis Factor-alpha/biosynthesis
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