Crosscutting of the pollutants and building ventilation systems: a literature review.

Considering the time spent in enclosed environments, it is essential to study the relationship between pollutants and building ventilation systems to find whether the types and levels of pollutants and greenhouse gasses, which are expected to be exhaled through ventilation systems into the atmosphere, have been adequately evaluated. We propose the hypothesis that the exhaled air from residential buildings contains pollutants that may become another source of contamination affecting urban air quality and potentially contributing to climate drivers. Thus, the main goal of this article is to present a cross-review of the identification of pollutants expected to be exhaled through ventilation systems in residential buildings. This approach has created the concept of "exhalation of buildings" a new concept enclosed within the research project in which this article is included. We analyze the studies related to the most significant pollutants found in buildings and the studies about the relation of buildings' ventilation systems with such pollutants. Our results show that, on the one hand, the increase in the use of mechanical ventilation systems in residential buildings has been demonstrated to enhance the ventilation rate and generally improve the indoor air quality conditions. But no knowledge could be extracted about the corresponding environmental cost of this improvement, as no systematic data were found about the total mass of contaminants exhaled by those ventilation systems. At the same time, no projects were found that showed a quantitative study on exhalation from buildings, contrary to the existence of studies on pollutants in indoor air.

The Natural History of Kidney Graft Cortical Microcirculation Determined by Real-Time Contrast-Enhanced Sonography (RT-CES).

BACKGROUND: Kidney transplantation is the therapy of choice for end-stage kidney disease. Graft's life span is shorter than expected due in part to the delayed diagnosis of various complications, specifically those related to silent progression. It is recognized that serum creatinine levels and proteinuria are poor markers of mild kidney lesions, which results in delayed clinical information. There are many investigation looking for early markers of graft damage. Decreasing kidney graft cortical microcirculation has been related to poor prognosis in kidney transplantation. Cortical capillary blood flow (CCBF) can be measured by real-time contrast-enhanced sonography (RT-CES). Our aim was to describe the natural history of CCBF over time under diverse conditions of kidney transplantation, to explore the influence of donor conditions and recipient events, and to determine the capacity of CCBF for predicting renal function in medium term. PATIENTS AND METHODS: RT-CES was performed in 79 consecutive kidney transplant recipients during the first year under regular clinical practice. Cortical capillary blood flow was measured. Clinical variables were analyzed. The influence of CCBF has been determined by univariate and multivariate analysis using mixed regression models based on sequential measurements for each patient over time. We used a first-order autoregression model as the structure of the covariation between measures. The post-hoc comparisons were considered using the Bonferroni correction. RESULTS: The CCBF values varied significantly over the study periods and were significantly lower at 48 h and day 7. Brain-death donor age and CCBF levels showed an inverse relationship (r: -0.62, p<0.001). Living donors showed higher mean CCBF levels than brain-death donors at each point in the study. These significant differences persisted at month 12 (54.5 ± 28.2 vs 33.7 ± 30 dB/sec, living vs brain-death donor, respectively, p = 0.004) despite similar serum creatinine levels (1.5 ± 0.3 and 1.5 ± 0.5 mg/dL). A sole rejection episode was associated with lower overall CCBF values over the first year. CCBF defined better than level of serum creatinine the graft function status at medium-term. CONCLUSION: RT-CES is a non-invasive tool that can quantify and iteratively estimate cortical microcirculation. We have described the natural history of cortical capillary blood flow under regular clinical conditions.