ABSTRACT
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Subject(s)
Humans , Male , Child , Leishmaniasis, Cutaneous/therapy , Photochemotherapy/methods , Eyelids/drug effects , Eyelids/pathology , MicroscopyABSTRACT
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Subject(s)
Humans , Male , Child , Muscular Atrophy/chemically induced , Muscular Atrophy/complications , Muscular Atrophy/diagnosis , Penicillin G Benzathine/administration & dosage , Penicillin G Benzathine/adverse effects , Adrenal Cortex Hormones/therapeutic use , Drug-Related Side Effects and Adverse Reactions/complications , Drug-Related Side Effects and Adverse Reactions/drug therapy , Muscular Atrophy/drug therapy , Muscular Atrophy , Biopsy/methodsABSTRACT
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Subject(s)
Aged , Female , Humans , Pseudoxanthoma Elasticum/diagnosis , Elastic Tissue/physiopathology , Diagnosis, Differential , Dermis/pathologySubject(s)
Carcinoma, Verrucous/pathology , Head and Neck Neoplasms/pathology , Scalp , Skin Neoplasms/pathology , Tumor Burden , Adult , Female , HumansABSTRACT
El pioderma gangrenoso es una enfermedad perteneciente al grupo de las dermatosis neutrofílicas. Además de una clínica cutánea característica puede presentar manifestaciones viscerales. Presentamos el caso de una mujer de 34 años con un brote de pioderma gangrenoso exacerbado por yodo, con afectación pulmonar, y revisamos otros casos de pioderma gangrenoso con afectación pulmonar publicados hasta la fecha. Discutimos la posible implicación del yodo como factor de exacerbación del pioderma gangrenoso. Destacamos la afectación pulmonar como manifestación extracutánea más frecuente de esta entidad, y recordamos la granulomatosis de Wegener como principal diagnóstico diferencial del pioderma gangrenoso con afectación pulmonar. Es importante considerar la posible presentación de manifestaciones extracutáneas en el pioderma gangrenoso, entre las que destaca la afectación pulmonar, para evitar técnicas diagnósticas agresivas, al menos inicialmente (AU)
Pyoderma gangrenosum is a neutrophilic dermatosis that, in addition to its characteristic skin manifestations, can cause visceral alterations. Our patient was a 34-year-old woman with pyoderma gangrenosum that was exacerbated by iodine and that also affected the lungs. Other published cases of lung involvement in pyoderma gangrenosum are reviewed and we discuss the possible exacerbation of this disease by iodine. Lung involvement is the most common extracutaneous manifestation of pyoderma gangrenosum and the main differential diagnosis is then with Wegener granulomatosis. It is important to remember the possible presentation of extracutaneous manifestations of pyoderma gangrenosum, including particularly lung involvement, in order to avoid subjecting a patient to aggressive diagnostic tests, at least in the initial stages (AU)
Subject(s)
Humans , Female , Adult , Pyoderma Gangrenosum/complications , Lung Diseases/etiology , Iodine/adverse effects , Diagnosis, Differential , Granulomatosis with Polyangiitis/diagnosis , Pyoderma Gangrenosum/diagnosisABSTRACT
El hamartoma angiomatoso ecrino es un tumor benigno e infrecuente que se caracteriza por la proliferación de elementos ecrinos y vasculares. Presentamos dos casos, el de una mujer de 33 años que consultó por una lesión marronácea en la espalda, con hiperhidrosis asociada, y el de un varón de 25 años con una lesión eritematosa, asintomática, en la palma izquierda. Tras el estudio histológico ambos pacientes se diagnosticaron de hamartoma angiomatoso ecrino. El hamartoma angiomatoso ecrino generalmente se presenta al nacimiento o en la infancia. Se manifiesta habitualmente como una lesión única con presentación clínica variable, por lo que su diagnóstico es fundamentalmente histológico. La localización más frecuente es la región distal de las extremidades. Suele ser asintomático, pero puede haber dolor e hiperhidrosis asociados. No requiere tratamiento salvo en aquellos casos asociados a sintomatología recalcitrante, sudor excesivo o por motivos estéticos (AU)
Eccrine angiomatous hamartoma is a rare, benign tumor characterized by a proliferation of eccrine and vascular structures. We present 2 cases and review the characteristics of this disorder. The first patient was a 33-year-old woman who consulted for a brownish lesion on her back associated with local hyperhidrosis. The second patient was a 25-year-old man withan asymptomatic erythematous lesion on his left palm. In both patients a diagnosis of eccrine angiomatous hamartoma was made based on the histological findings. Eccrine angiomatous hamartoma is usually present at birth or develops during childhood. It is typically a solitary lesion and signs and symptoms can vary; diagnosis is therefore based on histological study. The most common site is on the distal parts of limbs. The lesions tend to be asymptomatic, but there may be associated pain and hyperhidrosis. Treatment is not usually necessary except in cases with persistent symptoms, excessive sweating, or cosmetic concern (AU)
Subject(s)
Humans , Animals , Male , Female , Adult , Hamartoma/diagnosis , Hamartoma/pathology , Hemangioma/diagnosis , Hemangioma/pathology , Acrospiroma/diagnosis , Acrospiroma/pathology , Hamartoma/etiology , Hamartoma/psychology , Hemangioma/psychology , Hemangioma/surgery , Hyperhidrosis/complications , Hyperhidrosis/pathology , Histology/education , Histology/statistics & numerical data , Histology/trendsABSTRACT
Eccrine angiomatous hamartoma is a rare, benign tumor characterized by a proliferation of eccrine and vascular structures. We present 2 cases and review the characteristics of this disorder. The first patient was a 33-year-old woman who consulted for a brownish lesion on her back associated with local hyperhidrosis. The second patient was a 25-year-old man with an asymptomatic erythematous lesion on his left palm. In both patients a diagnosis of eccrine angiomatous hamartoma was made based on the histological findings. Eccrine angiomatous hamartoma is usually present at birth or develops during childhood. It is typically a solitary lesion and signs and symptoms can vary; diagnosis is therefore based on histological study. The most common site is on the distal parts of limbs. The lesions tend to be asymptomatic, but there may be associated pain and hyperhidrosis. Treatment is not usually necessary except in cases with persistent symptoms, excessive sweating, or cosmetic concerns.
Subject(s)
Eccrine Glands/pathology , Hemangioma/pathology , Sweat Gland Neoplasms/pathology , Adult , Aluminum Hydroxide/therapeutic use , Antiperspirants/therapeutic use , Female , Hand , Hemangioma/complications , Humans , Hyperhidrosis/drug therapy , Hyperhidrosis/etiology , Male , Shoulder , Sweat Gland Neoplasms/complicationsABSTRACT
Pyoderma gangrenosum is a neutrophilic dermatosis that, in addition to its characteristic skin manifestations, can cause visceral alterations. Our patient was a 34-year-old woman with pyoderma gangrenosum that was exacerbated by iodine and that also affected the lungs. Other published cases of lung involvement in pyoderma gangrenosum are reviewed and we discuss the possible exacerbation of this disease by iodine. Lung involvement is the most common extracutaneous manifestation of pyoderma gangrenosum and the main differential diagnosis is then with Wegener granulomatosis. It is important to remember the possible presentation of extracutaneous manifestations of pyoderma gangrenosum, including particularly lung involvement, in order to avoid subjecting a patient to aggressive diagnostic tests, at least in the initial stages.
Subject(s)
Lung Diseases/etiology , Pyoderma Gangrenosum/complications , Adult , Female , HumansSubject(s)
Lichen Planus/pathology , Aged , Female , Humans , Lichen Planus/complications , Skin Diseases/complications , Skin Diseases/pathologyABSTRACT
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Subject(s)
Humans , Female , Aged , Lichen Planus/diagnosis , Erythema/diagnosis , Isotretinoin/therapeutic use , Dyskeratosis Congenita/diagnosis , Diagnosis, DifferentialABSTRACT
BACKGROUND: Toenail disorders are frequent, especially onychomycosis. The interobserver variability of nail signs needs to be known before these signs can be confidently applied for diagnosis. OBJECTIVES: To describe observer agreement in toenail findings as described by dermatologists in standard clinical practice, focusing on signs that could be useful for diagnosis of onychomycosis. METHODS: Prospective cross-sectional study in five dermatology departments. Eighty-six patients with abnormal toenails that could have onychomycosis as a differential diagnosis were independently examined by a pair of dermatologists using a predefined questionnaire, to describe the presence of 10 findings on previous history and 14 physical signs. RESULTS: Agreement was fine for previous history findings: it was very good (kappa > 0.81) for previous diagnosis of diabetes, smoking and use of public dressing rooms or swimming pools. Agreement was good (kappa 0.61-0.80) for immune suppression (drugs or cancer), previous diagnosis of fungal disease and worsening in the last year. It was moderate (kappa 0.41-0.60) for previous diagnosis of arterial disease, trauma induced by work or sports, and distal vs. proximal or lateral vs. central start of the lesion. Agreement was worse for physical signs: we found good agreement for the presence of the same disease in fingernails, abnormal plantar desquamation, deformity causing nail trauma, and subungual hyperkeratosis. It was moderate for the presence of nail destruction, tinea interdigitalis, onycholysis, and the type of material obtained by subungual curettage (dust vs. hard). Agreement was fair (kappa 0.21-0.40) for the presence of longitudinal or transverse striae, trachyonychia, pachyonychia, and change in colour of the nail plate. Pitting was too infrequent to allow for kappa calculation. Chance expected agreement was between 51% and 84% for all signs except pitting. CONCLUSIONS: Agreement is adequate for most signs. It is low for the presence of longitudinal or transverse striae, trachyonychia, and change in colour of the nail plate. Pitting is rare in toenails.
Subject(s)
Foot Dermatoses/diagnosis , Nail Diseases/diagnosis , Aged , Clinical Competence , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Nails , Observer Variation , Onychomycosis/diagnosis , Prospective Studies , Severity of Illness Index , Spain , Surveys and QuestionnairesSubject(s)
Acanthosis Nigricans/complications , Achondroplasia/complications , Acanthosis Nigricans/genetics , Adult , Female , Humans , PedigreeABSTRACT
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Subject(s)
Humans , Female , Adult , Acanthosis Nigricans/complications , Acanthosis Nigricans/diagnosis , Biopsy/methods , Papilloma/complications , Papilloma/diagnosis , Biomarkers/analysis , Acanthosis Nigricans/physiopathology , Acanthosis Nigricans/therapy , Acanthosis Nigricans/epidemiology , Acanthosis Nigricans/etiology , Acanthosis Nigricans/microbiologySubject(s)
Carcinoma, Basal Cell/diagnosis , Facial Neoplasms/diagnosis , Head and Neck Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Aged , Aged, 80 and over , Carcinoma, Basal Cell/surgery , Facial Neoplasms/surgery , Female , Head and Neck Neoplasms/surgery , Humans , Male , Skin Neoplasms/surgeryABSTRACT
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