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Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
Graebin, Cedric S; Madeira, Maria de F; Yokoyama-Yasunaka, Jenicer K U; Miguel, Danilo C; Uliana, Silvia R B; Benitez, Diego; Cerecetto, Hugo; González, Mercedes; Rosa, Ricardo Gomes da; Eifler-Lima, Vera Lucia.
Eur J Med Chem ; 45(4): 1524-8, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20116908

ABSTRACT

The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.


Subject(s)
Antiprotozoal Agents/pharmacology , Cyclohexenes/pharmacology , Leishmania/drug effects , Terpenes/pharmacology , Trypanosoma/drug effects , Animals , In Vitro Techniques , Limonene , Macaca mulatta , Magnetic Resonance Spectroscopy , Mass Spectrometry
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