Rare accessory slip of the deltoid muscle conjoined with teres minor

Routine dissection of a 69-year-old American Caucasian female revealed a unique accessory slip of the deltoid muscle which was conjoined with the proximal portion of teres minor. The variant muscle bundle was united with the distal portion of the deltoid, but deviated superomedially and fused with the origin of teres minor. This discovery possesses clinical relevance with respect to surgical repair of shoulder pathology or trauma. Shoulder injuries and their respective repairs are very common. Therefore, consideration of this variant is necessary for the correct diagnosis and treatment of massive trauma or other shoulder pathology that is refractory to standard treatments

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3D-model of adult cardiac stem cells promotes cardiac differentiation and resistance to oxidative stress.

The regenerative inadequacy of the injured myocardium leads to adverse remodeling, cardiac dysfunction, and heart disease. Stem cell-replacement of damaged myocardium faces major challenges such as inappropriate differentiation, cellular uncoupling, scar formation, and accelerated apoptosis of transplanted cells. These challenges can be met by engineering an in vitro system for delivering stem cells capable of cardiac differentiation, tissue integration, and resistance to oxidative stress. In this study, we describe the formation of three-dimensional (3D) cell aggregates ("cardiospheres") by putative stem cells isolated from adult dog myocardium using poly-L-ornithine. De novo formation of cardiospheres in growth factor-containing medium occurred over a period of 2-3 weeks, but accelerated to 2-3 days when seeded on poly-L-ornithine. Older cardiospheres developed foci of "beating" cells upon co-culture with rat neonatal cardiomyocytes. Cardiospheres contained cells that exhibited characteristics of undifferentiated cells; differentiating cardiomyocytes with organized contractile machinery; and vascular cells capable of forming "vessel-like" networks. They exhibited strong resistance to elevated concentrations of hydrogen peroxide in culture and survived subcutaneous injections without undergoing neoplastic transformation up to 3 weeks post-transplantation. These findings suggest that cardiospheres are potentially useful for delivering functional stem cells to the damaged heart.