ABSTRACT
Introdução: As estrias ocorrem pelo rápido estiramento da pele, típico da gestação. Tratamentos tópicos vêm sendo estudados para prevenir seu aparecimento. Objetivo: avaliar a eficácia preventiva de estrias de uma formulação tópica. Métodos: Avaliaram-se 75 gestantes entre 18 e 40 anos. A área tratada foi o abdome, e a área-controle, a face interna do antebraço, com e sem o produto de teste, avaliando-se: maciez, hidratação e elasticidade além de medidas biofísicas para elasticidade e hidratação. Resultados: Das 75 gestantes, 52 finalizaram o estudo; destas, 9,6% apresentaram estrias na área abdominal tratada. Houve melhora significativa em os todos parâmetros clínicos avaliados (p<0,001). Nas medidas instrumentais, houve melhora significativa da hidratação e elasticidade na área abdominal, superior à da área-controle; quanto ao antebraço, também houve melhora significativa da área tratada em relação ao controle para ambos os parâmetros avaliados (p = 0,001). Comentários e Conclusão: A associação dos ingredientes da formulação (ácido láctico e lactato de sódio em emulsão com triglicerídeos do ácido caprílico e cáprico) foi capaz de aumentar os níveis de elasticidade e hidratação, reduzindo a incidência de estrias em comparação ao relatado em literatura.
Introduction: Stretch marks occur due to the rapid stretching of the skin, which is typical in pregnancy. Several topical treatments to prevent them have been studied.Objective: To evaluate the effectiveness of a topical formulation (lactic acid and sodium lactate in an emulsion with caprylic and capric acids' triglycerides) in the prevention of stretch marks.Methods: Seventy-five pregnant women aged 18-40 were assessed. The treated area was the abdomen and the control area was the inner forearm, with and without the application of the tested product. Softness, hydration, and elasticity and biophysical measurements for hydration and elasticity were evaluated. Results: Of the 52 women who completed the study, 9.6% presented stretch marks in the treated abdominal area. There was a significant improvement in all clinical parameters assessed (p < 0.001). There was a significant improvement compared the control area in the instrumental measurements of hydration and elasticity in the abdomen. A significant improvement was also verified in the treated forearm area compared to the untreated forearm area for both parameters evaluated (p = 0.001).Conclusions: The formulation improved the skin's elasticity and hydration, reducing the striae incidence more than previously reported in the literature.
ABSTRACT
Emerging data reveal that oral estrogen therapy can increase clinic blood pressure (BP) in post-menopausal women; however, it is important to establish its effects on ambulatory BP, which is a better predictor for target-organ damage. Besides estrogen therapy, aerobic training is widely recommended for post-menopausal women, and it can decrease ambulatory BP levels. This study was designed to evaluate the effect of aerobic training and estrogen therapy on the ambulatory BP of post-menopausal women. Forty seven healthy hysterectomized women were randomly divided (in a double-blind manner) into 4 groups: placebo-control (PLA-CO=12), estrogen therapy-control (ET-CO=14), placebo-aerobic training (PLA-AT=12), and estrogen therapy-aerobic training (ET-AT=09). The ET groups received estradiol valerate (1 mg/day) and the AT groups performed cycle ergometer, 3×/week at moderate intensity. Hormonal status (blood analysis), maximal cardiopulmonary exercise test (VO(2) peak) and ambulatory BP (24-h, daytime and nighttime) was evaluated before and 6 months after interventions. A significant increase in VO(2) peak was observed only in women who participated in aerobic training groups (+4.6±1.0 ml kg(-1) min(-1), P=0.00). Follicle-stimulating hormone was a significant decreased in the ET groups (-18.65±5.19 pg/ml, P=0.00), and it was accompanied by an increase in circulating estrogen (56.1±6.6 pg/ml). A significant increase was observed in the ET groups for daytime (P=0.01) and nighttime systolic BP (P=0.01), as well as nighttime diastolic BP (P=0.02). However, daytime diastolic BP was increased only in the ET-CO group (+3.4±1.2 mmHg, P=0.04), and did not change in any other groups. No significant effect was found in ambulatory heart rate. In conclusion, aerobic training abolished the increase of daytime ambulatory BP induced by estrogen therapy in hysterectomized, healthy, normotensive and postmenopausal women.
Subject(s)
Blood Pressure/physiology , Estrogen Replacement Therapy/adverse effects , Exercise/physiology , Blood Pressure Monitoring, Ambulatory , Double-Blind Method , Estrogens/blood , Female , Follicle Stimulating Hormone/blood , Humans , Hysterectomy , Middle Aged , Oxygen Consumption , Postmenopause/blood , Postmenopause/physiologyABSTRACT
Avaliar os efeitos de um preparado injetavel mensal contendo enantato de noretisterona 50 mg + valerato de estradiol 5 mg, sobre os niveis pressoricos e...
Subject(s)
Humans , Female , Adult , Middle Aged , Injections, Intramuscular/methods , Menopause , Hormone Replacement Therapy/methods , Hypertension/etiology , Norethindrone , Time FactorsABSTRACT
Em estudo randomizado, duplo-cego controlado com placebo avaliou-se os efeitos da terapia estrogênica oral e do exercício físico aeróbio supervisionado sobre parâmetros de risco cardiovascular na pós-menopausa. Ao longo de 6 meses, 24 mulheres histerectomizadas saudáveis na pós-menopausa receberam valerato de estradiol 1 mgdia por via oral contínuo ou placebo, e realizaram treinamento físico aeróbio supervisionado ou permaneceram sedentárias. /In a double-blinded placebo controlled study the effects of oral estrogenic therapy and aerobic exercise training program on some cardiovascular risk factors in postmenopausal women were evaluated. During 6 months, 24 hysterectomized healthy postmenopausal women, were randomly assigned to receive continuous oral estradiol valerate 1 mg/day or placebo, and were enrolled in a supervised aerobic exercise training program or remained sedentary...
Subject(s)
Humans , Female , Adult , Middle Aged , Cardiovascular Diseases/prevention & control , Estrogen Replacement Therapy , Postmenopause , Double-Blind Method , Exercise , Physical Fitness , Risk FactorsABSTRACT
Objetivo: O objetivo deste estudo foi avaliar os efeitos de uma associacao estro-progestogenica contendo valerato de estradiol associado a progestogeno derivado de 19-nortestosterona sobre os niveis presssoricos, perfil lipidico e outros...
Subject(s)
Humans , Female , Adult , Middle Aged , Hypertension/therapy , Premenopause , Hormone Replacement Therapy/methods , Estradiol , Premenopause/metabolism , Arterial Pressure , ProgesteroneABSTRACT
O presente estudo teve como objetivo avaliar clinica e laboratorialmente mulheres climatericas portadores de Artrite Reumatoide (AR) submetidas a 3 diferentes esquemas de Terapia de Reposicao Hormonal (TRH). Foram avaliadas 37 mulheres climatericas com idades variando entre 39 e 61 anos (media etaria de 51,6 anos), portadoras de AR recebendo 3 diferentes esquemas de TRH por via oral. As mulheres foram divididas em 3 grupos de acordo com os esquemas de TRH: Grupo A- 9 mulheres utilizaram a associacao 17beta estradiol 2 mg/dia + acetato de noretisterona 1 mg/dia em esquema continuo; Grupo B- 6 mulheres histerectomizadas utilizaram...
