ABSTRACT
Colorectal cancer is the second leading cause of cancer death in the developed world, due to formation of distant metastases. The liver is the primary target organ of metastatic lesions, which substantially influence the morbidity of the disease. At the time of diagnosis of colorectal cancer, about 15% to 20% of patients are found to have synchronous liver metastases and an average of 25% of all patients will develop metachronous liver metastases in the course of their disease. Prompt diagnosis of colorectal liver metastases leads to early treatment, which favours a better prognosis. Consequently, the diagnostic process has shifted from traditional clinical procedures to technologically advanced imaging modalities, such as CT, MRI, FDG-PET and PET-CT. The only curative therapy of colorectal liver metastases is surgical resection using the new methods of tissue excision and haemostasis. Depending on the number of metastases, the location, the volume, the extrahepatic spread and the overall condition of the patient, complete resection is only possible in 20% of all cases. If resection is not feasible, a large number of systemic or local palliative treatment options are available.
Subject(s)
Colorectal Neoplasms/pathology , Colorectal Neoplasms/surgery , Hepatectomy , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Algorithms , Antineoplastic Agents/therapeutic use , Chemotherapy, Adjuvant , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/drug therapy , Hepatectomy/methods , Humans , Liver Neoplasms/diagnosis , Liver Neoplasms/drug therapy , Prognosis , Survival Analysis , Treatment OutcomeABSTRACT
Castleman's disease is a rare disorder characterized by proliferation of the lymphoid tissue. Castleman's disease affects both males and females, and may occur at any age. Little is known about how often Castleman's disease actually occurs, other than it is rare, or what causes the disease. The most frequent location of the disease is the mediastinum. The location of the disease in the retroperitoneum is rare and it is usually associated with the generalized form of the disease. We report a case of a 34-year old man with isolated retroperitoneum Castleman's disease of the hyaline-vascular type, which presented as a palpable abdominal mass. The final diagnosis was reached after exploratory laparotomy and resection of the tumor.
