History of surgery for breast cancer: radical to the sublime.

The historic milestones that have brought the surgical management of breast cancer to its current state are recounted. The Halsted radical mastectomy, once considered the ideal cancer operation, no longer has a place in the routine management of patients with breast cancer. Breast conservation in the form of segmental mastectomy, axillary node dissection, and radiation is often chosen over the modified radical mastectomy, popular in the 1980s. Axillary lymphadenectomy, shown to be of questionable therapeutic value in breast cancer, is certainly of prognostic significance. Studies are ongoing to establish the validity of the less-invasive sentinel node biopsy in determining axillary nodal status. Perhaps the most significant change in today's approach to breast cancer is the reliance on well-controlled prospective studies to evaluate outcome and determine the appropriate surgical procedure.

Mucinous cystadenoma of the appendix: diagnosis, surgical management, and follow-up.

PURPOSE: To review the diagnostic examination and clinical presentation of mucinous cystadenoma of the appendix. METHODS: Case report from experience at an Air Force tertiary care hospital in a 66-year-old woman with chronic right lower quadrant pain. RESULTS: After extensive preoperative evaluation and subsequent diagnostic laparoscopy, a right hemicolectomy was performed for a mucinous cystadenoma of the appendix. CONCLUSIONS: Appendiceal mucinous cystadenoma is a rare entity found in only 0.3% of appendiceal specimens. Preoperative evaluation with radiologic and endoscopic methods is helpful but not always diagnostic. Although a benign disease process, complications from rupture, invasion into adjacent organs, or recurrence warrant adherence to strict oncologic principles for resection.

The spectrum of treatment and future diagnosis of early non-small cell lung carcinoma.

PURPOSE: Review the surgical treatment of 56 patients at a single institution of early stage non-small cell lung carcinoma (NSCLC). Briefly review the literature to report the current indications for limited pulmonary resection. Discuss newer methods of assessing early stage NSCLC. METHODS: We reviewed 56 lobectomies performed at the Biloxi Veterans Administration Medical Center from January 1992 to December 1997 for NSCLC to report the incidence of N1 positive lymph nodes and survival data. Additionally, a search of PubMed, Ovid, and MDConsult.com, using search parameters of non-small cell lung carcinoma, limited pulmonary resection, lobectomy, and comorbidity, were used to determine indications for treating non-small cell lung carcinoma. RESULTS: N1 positive lymph nodes occurred in 11 out of 56 patients; 4 were identified preoperatively. In this sample, 21 patients were Stage IA, 21 Stage IB, 6 Stage IIA, and 8 Stage IIB, and their 4-year median survival was as follows: (IA) greater than 44.80 months, (IB) greater than 48.0 months, (IIA) greater than 25.28 months, and (IIB) = 11.18 months. Four-year survival rates by stage were IA= 10/21 (47.62%), IB= 14/21 (66.67%), IIA= 2/6 (33.33%), and IIB= 0/8 (0.0%). CONCLUSIONS: The 4-year survival data we reviewed were less favorable than is reported by others. Patient medical comorbidity, patient age, and sample size are thought to account for this difference. According to our literature review, reasons for limited pulmonary resection include poor physical performance, marginal lung reserve, synchronous bilateral tumors, and superior sulcus tumors (T3) in which the tumor primarily invades the chest wall. Heavier consideration of these indications might have improved the outcomes seen in this population.