[Psychological Effects of the COVID-19 Pandemic on Freelance Professional Musicians]. / Psychische Auswirkungen der COVID-19-Pandemie bei freiberuflichen Berufsmusiker*innen.

With the onset of public life restrictions in the COVID 19 pandemic in March 2020, freelance professional musicians were exposed to significant pandemic-related restrictions in exercising their profession. Due to the particular working conditions, this professional group was already considered high at risk in terms of mental health before the pandemic. The present study investigates the level of mental distress among professional musicians during the pandemic in relation to basic mental health needs and help-seeking behaviour. In July and August 2021, psychological distress was measured in a nationwide sample of N=209 professional musicians using the ICD-10 Symptom Checklist (ISR). In addition, the extent to which the musicians' basic psychological needs are met and whether they would seek professional psychological help was determined. Compared to various control groups before and during the pandemic, professional musicians showed significantly higher levels of psychological symptoms than the general population before and during the pandemic. Regression analyses support the assumption that pandemic-related changes in the basic psychological needs of pleasure or displeasure avoidance, self-esteem enhancement or self-esteem protection and attachment have a significant influence on the expression of depression symptoms. The musicians' help-seeking behaviour, on the other hand, decreases with an increase in depression symptoms. Due to the high overall psychological stress among freelance musicians, there is a need for action, especially in the provision of specially adapted psychosocial support services.

Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

Osteoporosis induction in a sheep model by steroid administration combined with ovariectomy recapitulates decreased bone formation and substandard matrix mineralization in patients. Recently, the role of osteocytes has been frequently addressed, with focus on their role in osteoclastogenesis. However, the quantification of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) signaling in osteocytes was not studied in sheep. The current study reproduced the sheep model of osteoporosis to study the RANKL/OPG ratio correlation to the method of osteoporosis induction. We investigated the induction of osteoporosis after 8 months using 31 female merino land sheep divided into four groups: control, ovariectomy, ovariectomy with dietary limitation, and ovariectomy with dietary limitation and steroid injection. In accordance to previous reports, the present study showed trabecular thinning, higher numbers of apoptotic osteocytes, and imbalanced metabolism, leading to defective mineralization. The global RANKL/OPG ratio in the spine after 8 months of steroid and dietary treatment was not different from that of the control. Interestingly, assessment of the osteocyte-specific RANKL/OPG ratio showed that the steroid-induced osteoporosis in its late progressive phase stimulates RANKL expression in osteocytes. Sclerostin is suggested to induce RANKL expression in osteocytes. The findings of this study can contribute to further explain the success of sclerostin antibodies in treating osteoporotic patients despite increased osteocyte-expressed RANKL.