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Bioorg Med Chem Lett
; 14(10): 2643-5, 2004 May 17.
Article
in English
| MEDLINE
| ID: mdl-15109669
ABSTRACT
The HIV protease inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure-activity relationships explored.