ABSTRACT
BACKGROUND AND OBJECTIVE: A randomized prospective comparison of sub-Tenon's administration of mitomycin-C (MMC) with intrascleral administration of MMC in trabeculectomy was performed to determine whether intrascleral application is superior to the standard sub-Tenon's application. PATIENTS AND METHODS: Twenty-four eyes of 23 patients were randomized to treatment with MMC (0.27 mg/ml for 5 minutes). The route of administration was subconjunctival in group A and intrascleral in group B. Preoperative and postoperative visual acuity (VA), intraocular pressure (IOP), number of medications, and complications were compared between the two groups. RESULTS: There was no statistically significant difference between the two groups preoperatively regarding VA, IOP, and number of medications. Postoperatively, IOP and number of medications required had decreased significantly in both groups. A significantly larger number of postoperative procedures were required in group B to control IOP (group A = 3, group B = 14, P = .002). CONCLUSION: Both methods of MMC application significantly decreased the IOP and the number of medicines required to control IOP after trabeculectomy. The intrascleral use of MMC resulted in the need for more surgery postoperatively (P = .002).
Subject(s)
Glaucoma, Open-Angle/surgery , Mitomycin/administration & dosage , Nucleic Acid Synthesis Inhibitors/administration & dosage , Postoperative Complications/prevention & control , Trabeculectomy/methods , Aged , Aged, 80 and over , Chemotherapy, Adjuvant , Conjunctiva , Drug Administration Routes , Female , Follow-Up Studies , Glaucoma, Open-Angle/drug therapy , Glaucoma, Open-Angle/physiopathology , Humans , Injections , Intraocular Pressure , Male , Middle Aged , Ophthalmic Solutions , Postoperative Complications/drug therapy , Postoperative Complications/physiopathology , Prospective Studies , Sclera , Visual AcuityABSTRACT
A method has been developed for calculating the maximum permissible exposure for multiple wavelength lasers used in scanning laser ophthalmoscope systems. The method is based on the assumption that when the human eye is simultaneously exposed to multiple wavelength laser light, the thermal and photochemical effects on the retina are additive and independent of each other. A linear addition method is used to calculate multiple laser maximum permissible exposures for scanning laser ophthalmoscope systems. This paper also includes a discussion of possible synergistic effects of retinal biological effects caused by multiple laser exposure. An example is given to illustrate a conservative, theoretical approach to estimating the maximum permissible exposure for simultaneous multiple wavelength laser exposure.
Subject(s)
Ophthalmoscopes , Humans , Lasers , Maximum Allowable Concentration , SafetyABSTRACT
Biobehavioral monitoring is a method of gathering daily biological and behavioral measurements from ambulatory patients so that hospital-based care can be extended to the home. Such data can also serve many other purposes such as peer review and assesing the outcome of treatment. To assist in handling the increased information about patients, NEW, a system of three interactive APL Plus computer program packages, has been developed. The program packages, NEWDATA, EVALUATION, and WARNINGS, form an interactive data management system to provide: a rapid means of entering and verifying each patient's data from either a single day or a group of days; a flexible and simple means of retrieving and analyzing the data for an individual patient or for groups of patients; and a means of reviewing, detecting, and signaling trends in the data that deviate from present clinical criteria.
