1.
Org Lett
; 2(15): 2361-4, 2000 Jul 27.
Article
in English
| MEDLINE
| ID: mdl-10930284
ABSTRACT
The scope and limitations of a tandem 5-exo dig cyclization/Claisen rearrangement sequence involving appropriately substituted 4-alkyn-1-ols as an efficient "one-pot" route to fused tricyclic ring systems is described. The reaction rates were found to be strongly dependent on the nature of the terminal substitutent of the triple bond. In some cases the entire sequence was found to proceed in good yield at temperatures as low as 115 degrees C.