ABSTRACT
Head and neck cancers (HNCs) are malignant tumors of the upper aerodigestive tract and are the sixth most common cancer worldwide. In India, around 30-40% of all cancers are HNCs. Even though there are global guidelines or recommendations for the management of HNCs, these may not be appropriate for Indian scenarios. In an effort to discuss current practices, latest developments and to come to a consensus to recommend management strategies for different anatomical subsites of HNCs for Indian patients, a group of experts (medical, surgical and radiation oncologists and dentists) was formed. A review of literature from medical databases was conducted to provide the best possible evidence base, which was reviewed by experts during a consensus group meeting (January, 2019) to provide recommendations.
Subject(s)
Head and Neck Neoplasms/therapy , Medical Oncology/standards , Squamous Cell Carcinoma of Head and Neck/therapy , Combined Modality Therapy/standards , Consensus , Head and Neck Neoplasms/diagnosis , Humans , India , Medical Oncology/methods , Patient Care Team/standards , Practice Guidelines as Topic , Practice Patterns, Physicians' , Prognosis , Squamous Cell Carcinoma of Head and Neck/diagnosisSubject(s)
Medical Oncology/standards , Mouth Neoplasms/therapy , Squamous Cell Carcinoma of Head and Neck/therapy , Combined Modality Therapy/standards , Consensus , Disease Management , Humans , India , Medical Oncology/methods , Mouth Neoplasms/diagnosis , Patient Care Team/standards , Practice Patterns, Physicians' , Prognosis , Squamous Cell Carcinoma of Head and Neck/diagnosisSubject(s)
Combined Modality Therapy/standards , Medical Oncology/standards , Nasopharyngeal Carcinoma/therapy , Nasopharyngeal Neoplasms/therapy , Consensus , Disease Management , Humans , India , Medical Oncology/methods , Nasopharyngeal Carcinoma/diagnosis , Nasopharyngeal Neoplasms/diagnosis , Patient Care Team/standards , Practice Patterns, Physicians'/standards , PrognosisSubject(s)
Medical Oncology/standards , Oropharyngeal Neoplasms/therapy , Squamous Cell Carcinoma of Head and Neck/therapy , Combined Modality Therapy/standards , Consensus , Disease Management , Humans , India , Oropharyngeal Neoplasms/diagnosis , Patient Care Team/standards , Practice Patterns, Physicians'/standards , Prognosis , Squamous Cell Carcinoma of Head and Neck/diagnosisSubject(s)
Hypopharyngeal Neoplasms/therapy , Medical Oncology/standards , Combined Modality Therapy/standards , Consensus , Disease Management , Humans , Hypopharyngeal Neoplasms/diagnosis , India , Medical Oncology/methods , Patient Care Team/standards , Practice Patterns, Physicians'/standards , PrognosisSubject(s)
Head and Neck Neoplasms/therapy , Medical Oncology/standards , Squamous Cell Carcinoma of Head and Neck/therapy , Combined Modality Therapy/standards , Consensus , Disease Management , Head and Neck Neoplasms/pathology , Humans , India , Medical Oncology/methods , Patient Care Team/standards , Practice Guidelines as Topic/standards , Practice Patterns, Physicians'/standards , Prognosis , Squamous Cell Carcinoma of Head and Neck/pathologyABSTRACT
BACKGROUND & AIM: Adenoid cystic carcinoma (ACC) of lacrimal gland is a rare tumour with aggressive behaviour. There is sparse data to address optimum therapy for such tumours. So, the present study was aimed at evaluating the role of adjuvant three dimensional conformal radiotherapy (3D-CRT) in cases of incomplete (R1) resection along with review of literature pertaining to management of lacrimal adenoid cystic carcinoma. MATERIALS AND METHODS: We retrospectively reviewed the demographic and treatment data of 10 biopsy proven ACC of lacrimal gland patients, treated from December 2006 to June 2013. They were treated with radiotherapy following surgical resection. Eight patients underwent gross total excision of the tumour mass (enbloc excision) followed by conformal radiotherapy to a dose of 60 Gray/30fractions/ 6 weeks. Two patients with advanced disease were treated with palliative radiotherapy after biopsy. RESULTS: The median age was 32 years. There were equal numbers of male and female patients. The median duration of symptoms was 7 months. At a median follow up of 21 months, eight patients had no evidence of disease and had complete tumour response, two patients worsened, and one of the two had systemic failure with bone metastasis. CONCLUSION: Despite a small sample size and short follow, enbloc surgical excision with adjuvant radiotherapy is well tolerated and shows good control in ACC of lacrimal gland.
ABSTRACT
PURPOSE: To analyze the clinical outcome of primary orbital lymphoma (POL) patients treated with a combined modality approach with local radiotherapy after induction chemotherapy. METHODOLOGY: We retrospectively retrieved demographic, treatment and outcome data of patients treated for POL from 2000 to 2010. The charts were reviewed and the data were tabulated in a predesigned pro-forma. RESULTS: 23 patients of POL were found evaluable. Median age was 55 years (range 24-70 years). Of 23 patients, 15 were male and 8 female, making the male:female ratio approximately 1.9:1. Patients were thoroughly evaluated and staged. All but one patient received multi agent chemotherapy. Radiotherapy was delivered for all cases. Radiation was delivered by 3DCRT technique. Median dose of radiation was 45Gy (range 20-45Gy). Median follow up was 26.8 months. None of the patients had any evidence of local failure or systemic progression. CONCLUSION: A combined modality therapy with a combination of CHOP/COP based chemotherapy and moderate dose of radiotherapy imparts excellent long term local and systemic disease control.
