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1.
Haemophilia ; 6(3): 162-9, 2000 May.
Article in English | MEDLINE | ID: mdl-10792474

ABSTRACT

We hypothesized that magnetic resonance imaging (MRI) scans taken prior to radiosynoviorthesis may be predictive of response to the procedure in persons with haemophilia. Specifically, response would be inversely related to the severity of synovial hyperplasia. Radiosynoviorthesis was administered to 21 joints with recurrent haemorrhage (target joints). A detailed self-report of haemorrhage history, joint evaluation with scoring according to the World Federation of Haemophilia orthopaedic joint and pain scales, plain radiographs, and MRI studies of the joints were performed pre- and post-radiosynoviorthesis. To augment comparison of the MRI findings to those assessed using the Arnold-Hilgartner and Pettersson scales, a provisional MRI scale for evaluation of haemophilic arthropathy was designed. We found the MRI findings prior to the procedure were not predictive of clinical response; independent of the severity of synovial hyperplasia, most joints bled less and showed improvement by the WFH orthopaedic score. There was generally no change in the severity of synovial hyperplasia after the procedure. We conclude that MRI evaluation is not routinely indicated prior to radiosynoviorthesis.


Subject(s)
Hemarthrosis/diagnosis , Hemarthrosis/radiotherapy , Hemophilia A/complications , Magnetic Resonance Imaging , Adolescent , Adult , Ankle/pathology , Ankle/radiation effects , Child , Elbow/pathology , Elbow/radiation effects , Follow-Up Studies , Hemarthrosis/etiology , Hemophilia A/blood , Hemophilia A/pathology , Hemophilia A/radiotherapy , Hemophilia B/blood , Hemophilia B/complications , Hemophilia B/pathology , Humans , Hyperplasia/diagnosis , Hyperplasia/diagnostic imaging , Hyperplasia/radiotherapy , Knee/pathology , Knee/radiation effects , Phosphorus Radioisotopes/therapeutic use , Radiography , Severity of Illness Index , Synovial Membrane/pathology , Synovial Membrane/radiation effects
2.
J Thorac Cardiovasc Surg ; 116(2): 242-52, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9699576

ABSTRACT

OBJECTIVES: Our objectives were to (1) review our experience with heart transplants in infants (age < 6 months), (2) delineate risk factors for 30-day mortality, and (3) compare outcomes between our early and recent experience. METHODS: Records of all infants listed for transplantation in our center before September 1996 were analyzed. Early and recent comparisons were made between chronologic halves of the accrual period. Univariate analysis was used to analyze potential risk factors for 30-day mortality (categorical variables, Fisher's exact test; continuous variables, nonparametric Wilcoxon rank-sum test). Multivariable analysis included univariate variables with p values < or = 0.10. Actuarial survivals were estimated (Kaplan-Meier) and compared by the log-rank test. RESULTS: Fifty-one of the 60 infants listed for transplantation were operated on (waiting list mortality 15%). Thirty-day mortality was 18% overall, 30% in the first 3 years and 10% in the last 3 years (p = 0.07). Sepsis was the commonest cause of early death (4/9). Univariate analysis suggested four potential risk factors for early death: preoperative mechanical ventilation (p = 0.01), prior sternotomy (p = 0.002), preoperative inotropic drugs (p = 0.08), and warm ischemia time (p = 0.08). Multivariable analysis indicated that prior sternotomy (p = 0.01) was an independent risk factor for 30-day mortality. Actuarial survivals were 80%, 78%, and 70% at 1, 2, and 3 years, and these figures improved between early and recent groups (p = 0.05). Late deaths were most commonly due to acute rejection (3/5). CONCLUSIONS: Results of heart transplantation in infancy improve with experience. Prior sternotomy increases initial risk. Intermediate-term survival for infants with end-stage heart disease is excellent.


Subject(s)
Heart Defects, Congenital/surgery , Heart Transplantation , Case-Control Studies , Female , Follow-Up Studies , Graft Rejection/mortality , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/mortality , Heart Transplantation/mortality , Humans , Infant , Infant, Newborn , Male , Multivariate Analysis , Postoperative Complications/mortality , Retrospective Studies , Survival Rate , Treatment Outcome
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