ABSTRACT
Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy (AU)
Subject(s)
Humans , Male , Female , Skin Neoplasms/drug therapy , Skin Neoplasms/metabolism , Skin Neoplasms/radiotherapy , Skin Neoplasms/diagnosis , Neoplasms/mortality , Neoplasms/pathology , Neoplasms, Squamous Cell/diagnosisABSTRACT
Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.
Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Carcinoma, Squamous Cell/drug therapy , Drug Carriers , Lipids/chemistry , Nanoparticles , Skin Neoplasms/drug therapy , Emulsions , HumansABSTRACT
Tungiasis is an endemic disease in certain poor areas around the world. Imported infestations in travelers are becoming more frequent and can lead to considerable morbidity. We report a case of a 50 year-old-man who returned from a trip to Guinea-Bissau with an infection caused by Tunga penetrans.