1.
Bioorg Med Chem Lett
; 14(16): 4157-60, 2004 Aug 16.
Article
in English
| MEDLINE
| ID: mdl-15261261
ABSTRACT
The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
Subject(s)
Antiviral Agents/pharmacology , Herpesvirus 3, Human/drug effects , Thiourea/pharmacology , Antiviral Agents/chemistry , Microbial Sensitivity Tests , Structure-Activity Relationship , Thiourea/chemistry
2.
Bioorg Med Chem Lett
; 14(13): 3401-6, 2004 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-15177441
ABSTRACT
A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM.
Subject(s)
Antiviral Agents/chemical synthesis , Cytomegalovirus/drug effects , Herpesviridae/drug effects , Thiourea/analogs & derivatives , Antiviral Agents/pharmacology , Cells, Cultured , Drug Resistance, Microbial , Humans , Inhibitory Concentration 50 , Structure-Activity Relationship , Thiourea/pharmacology
3.
Bioorg Med Chem Lett
; 13(17): 2929-32, 2003 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-14611860
ABSTRACT
Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.
