From Waste to Value: Recent Insights into Producing Vanillin from Lignin.

Vanillin, one of the most widely used and appreciated flavoring agents worldwide, is the main constituent of vanilla bean extract, obtained from the seed pods of various members belonging to the Orchidaceae family. Due to the great demand in the food confectionery industry, as well as in the perfume industry, medicine, and more, the majority of vanillin used today is produced synthetically, and only less than one percent of the world's vanilla flavoring market comes directly from the traditional natural sources. The increasing global demand for vanillin requires alternative and overall sustainable new production methods, and the recovery from biobased polymers, like lignin, is an environmentally friendly alternative to chemical synthesis. The present review provides firstly an overview of the different types of vanillin, followed by a description of the main differences between natural and synthetic vanillin, their preparation, the market of interest, and the authentication issues and the related analytical techniques. Then, the review explores the real potentialities of lignin for vanillin production, presenting firstly the well-assessed classical methods and moving towards the most recent promising approaches through chemical, biotechnological and photocatalytic methodologies, together with the challenges and the principal issues associated with each technique.

Dependence of 1H-NMR T 1 relaxation time of trimethylglycine betaine deep eutectic solvents on the molar composition and on the presence of water.

1H-NMR spin lattice relaxation times (T 1), measured by inversion recovery technique, allowed to establish the stoichiometric coefficient (ratio between the H-bond acceptor and H-bond donor) of a series of trimethylglycine betaine/diol based deep eutectic solvents (DESs); ethylene glycol, triethylene glycol and 1,3-propandiol were selected as H-bond donors. The maximum amount of water tolerated by the DES, before its complete hydration, was determined as well. Finally, the method was validated comparing the eutectic composition of the betaine/glycol system with that determined by means of differential scanning calorimetry analysis; the stoichiometric coefficients were identical.