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1.
Res Vet Sci ; 96(1): 143-6, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24374119

ABSTRACT

This report describes the morphological and immunohistochemical features of intracytoplasmic inclusion bodies found in a 13-year-old Yorkshire dog with a hepatocellular carcinoma and referred for anorexia, lethargy and mild polydipsia. Fine-needle aspirates of the large abdominal mass revealed high number of pleomorphic neoplastic hepatocytes, containing round to polygonal, well-demarcated, hyaline bodies. Same findings were histologically confirmed on multiple biopsies. Immunohistochemically, the inclusion bodies were negative for alpha-1-antitrypsin, carcinoembryonary antigen, fibrinogen, IgG, IgM, cytokeratins 7, 8, 18, 19, 20. By transmission electron microscopy, the cytoplasmic inclusions were composed of granular homogeneous or reticulated electrondense matrix, enclosed within dilated rough endoplasmic reticulum or remnants of its membranes, consistent with proteinaceous material accumulated within neoplastic hepatocytes due to aberrant protein secretion or transport. This is the first detailed characterization of hyaline cytoplasmic inclusion bodies in canine hepatocellular carcinoma.


Subject(s)
Carcinoma, Hepatocellular/veterinary , Dog Diseases/pathology , Inclusion Bodies/pathology , Liver Neoplasms/veterinary , Animals , Carcinoma, Hepatocellular/diagnostic imaging , Carcinoma, Hepatocellular/pathology , Dog Diseases/diagnostic imaging , Dogs , Fatal Outcome , Hyalin/diagnostic imaging , Immunohistochemistry/veterinary , Inclusion Bodies/diagnostic imaging , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/pathology , Male , Microscopy, Electron, Transmission/veterinary , Ultrasonography
2.
J Feline Med Surg ; 9(3): 254-7, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17363314

ABSTRACT

Multilobular tumour of bone is a rare neoplasm of the skull in middle-aged, medium-to-large breed dogs even if a few cases have also been described in cats and one horse. The aim of the present paper is to show both the computed-tomography features and the pathological findings of the above neoplasm affecting the thoracic wall of a cat. To the best of the authors' knowledge, such anomalous tumour localisation has never been reported and imaged in feline medicine.


Subject(s)
Bone Neoplasms/veterinary , Cat Diseases/diagnostic imaging , Cat Diseases/pathology , Thoracic Neoplasms/veterinary , Animals , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Bone Neoplasms/surgery , Cat Diseases/surgery , Cats , Diagnosis, Differential , Male , Thoracic Neoplasms/diagnostic imaging , Thoracic Neoplasms/pathology , Tomography, X-Ray Computed/methods , Tomography, X-Ray Computed/veterinary
3.
J Vet Intern Med ; 21(6): 1251-7, 2007.
Article in English | MEDLINE | ID: mdl-18196734

ABSTRACT

BACKGROUND: Pituitary apoplexy in humans is a clinical syndrome resulting from sudden infarction, hemorrhage, or both in a normal or an adenomatous pituitary gland. OBJECTIVE: Describe a clinical syndrome in dogs similar to pituitary apoplexy in humans. ANIMALS: Four dogs exhibiting a sudden onset of neurologic signs. METHODS: A retrospective study was used, including clinical examination, computed tomography (CT), postmortem examination, and histopathology of the brain. Pituitary tissue from 3 of the dogs was subjected to immunocytochemistry. RESULTS: Four dogs (2 Mongrels, 1 Bordeaux Dog, and 1 Cocker Spaniel; median age, 11 years; median body weight, 20.5 kg) presented with acute neurologic signs including depression (n = 3), behavioral changes (n = 1), vision loss (n = 1), seizures (n = 1), and collapse (n = 1). CT disclosed suprasellar infarction, hemorrhage, or both associated with a pituitary macroadenoma in 3 dogs and a frank hemorrhage in a nonadenomatous pituitary gland in 1 dog. CT findings were correlated with postmortem findings, and pituitary apoplexy was confirmed by histopathology and immunocytochemistry of the pituitary tissue. CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides histopathologic evidence of pituitary apoplexy in dogs. The results are relevant for future diagnosis and treatment of pituitary disease in dogs.


Subject(s)
Dog Diseases/diagnosis , Pituitary Apoplexy/veterinary , Animals , Dog Diseases/pathology , Dogs , Female , Male , Pituitary Apoplexy/diagnosis , Pituitary Apoplexy/pathology
4.
Res Vet Sci ; 80(2): 186-8, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16098550

ABSTRACT

The aim of this study was to examine the expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas. STAT3 protein was demonstrated in both the cytoplasm and nuclei of labelled cells. The expression of STAT3 was observed in 87.50% (35/40) of both haemangiomas and haemangiosarcomas and 72.22% (13/18) of haemangiomas and 100% (22/22) haemangiosarcomas. The percentage of positive cells in haemangiomas and haemangiosarcomas was statistically significant difference (P<0.0001). These preliminary results indicate that STAT3 is overexpressed in malignant tumours.


Subject(s)
Dog Diseases/metabolism , Gene Expression Regulation, Neoplastic , Hemangioma/metabolism , Hemangioma/veterinary , Hemangiosarcoma/metabolism , Hemangiosarcoma/veterinary , STAT3 Transcription Factor/analysis , STAT3 Transcription Factor/immunology , Animals , Dogs , Immunohistochemistry
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