ABSTRACT
Examination and treatment of 70 patients, suffering an acute necrotic pancreatitits, was conducted. Content of presepsin, procalcitonin, Сreactive protein and interleukin6 (ÐL6) in the patients' blood plasma was determined, and bacteriological investiga' tions, contrastenhanced CT were conducted as well. Positive results of bacteriologi' cal investigations were noted in 43 patients. Level of presepsin and procalcitonin in patients, suffering purulentseptic complications, in 3 4 times exceeded such in a sterile pancreonecrosis. Presersin level,exceeding over 632 pg/ml, have permitted to confirm the presence of local and systemic infection with high specificity and sensitivi' ty, and this have exceeded diagnostic possibilities of the procalcitonin content determi' nation. High level of ÐL6 and Сreactive protein is characteristic for the systemic inflammatory response syndrome (SIRS) of infective and noninfective origin.
Subject(s)
Interleukin-6/blood , Lipopolysaccharide Receptors/blood , Pancreatitis, Acute Necrotizing/diagnosis , Peptide Fragments/blood , Sepsis/diagnosis , Systemic Inflammatory Response Syndrome/diagnosis , Adolescent , Adult , Aged , Biomarkers/blood , C-Reactive Protein/metabolism , Case-Control Studies , Female , Humans , Male , Middle Aged , Pancreatitis, Acute Necrotizing/blood , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/pathology , Procalcitonin/blood , Prospective Studies , ROC Curve , Sepsis/blood , Sepsis/complications , Sepsis/pathology , Systemic Inflammatory Response Syndrome/blood , Systemic Inflammatory Response Syndrome/complications , Systemic Inflammatory Response Syndrome/pathology , Tomography, Emission-ComputedABSTRACT
There were examined 113 patients, in whom an acute necrotic pancreatitis was diagnosed. While admittance to hospital a constant organ insufficiency was revealed in 50 (44%), a transient one--in 63 (56%) patients. In total 31 (27.4%) patients died. Respiratory insufficiency have occurred in 67% patients, and almost with similar rate--cardio-vascular (in 59%), renal (in 56%) and enteral (in 54%), dominating in the lethality structure. The BISAP (Bedcide Index for Severity in Acute Pancreatitis) scales applied permit with high probability to prognosticate the organ insufficiency and lethality in patients, suffering an acute necrotic pancreatitis.
Subject(s)
Heart Failure/diagnosis , Intestinal Pseudo-Obstruction/diagnosis , Pancreatitis, Acute Necrotizing/diagnosis , Renal Insufficiency/diagnosis , Respiratory Insufficiency/diagnosis , Adult , Female , Heart Failure/etiology , Heart Failure/mortality , Heart Failure/pathology , Humans , Intestinal Pseudo-Obstruction/etiology , Intestinal Pseudo-Obstruction/mortality , Intestinal Pseudo-Obstruction/pathology , Male , Middle Aged , Organ Dysfunction Scores , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/mortality , Pancreatitis, Acute Necrotizing/pathology , Prognosis , Renal Insufficiency/etiology , Renal Insufficiency/mortality , Renal Insufficiency/pathology , Respiratory Insufficiency/etiology , Respiratory Insufficiency/mortality , Respiratory Insufficiency/pathology , Severity of Illness Index , Survival AnalysisABSTRACT
In 12 patients with anaerobic sepsis, extracorporeal connection of donor spleen, its sections and transfusion of perfusates of xenospleen were used in the complex treatment. A positive result--reduction of intoxication, improvement of general state, normalization of immunologic indices--has been obtained.
Subject(s)
Bacteria, Anaerobic , Bacterial Infections/therapy , Sorption Detoxification/methods , Spleen , Animals , Female , Humans , Male , Remission Induction , Sorption Detoxification/instrumentationABSTRACT
In 28 patients with purulent septic diseases and in bench test of the donor conserved blood,it was established that ultraviolet irradiation was followed by improvement in the oxygen transport function of the blood, resulting from the formation of peroxide oxygen compounds and activation of carbohydrate metabolism.
