Subject(s)
Anemia, Hemolytic, Autoimmune/therapy , Hematopoietic Stem Cell Transplantation/methods , Salvage Therapy/methods , Waldenstrom Macroglobulinemia/therapy , Anemia, Hemolytic, Autoimmune/etiology , Disease Management , Humans , Immunosuppressive Agents/therapeutic use , Lymphoproliferative Disorders , Middle Aged , Sirolimus/therapeutic use , Tacrolimus/therapeutic use , Transplantation, Homologous , Waldenstrom Macroglobulinemia/complications , Waldenstrom Macroglobulinemia/pathologyABSTRACT
Myelin, the insulating sheath made by extensive plasma membrane wrapping, is dependent on the presence of highly adhesive molecules that keep the two sides of the membrane in tight contact. The Po glycoprotein (Po) is the major component of the peripheral nervous system (PNS) myelin of mammals. The exact role that Po protein has played in the evolution of myelin is still unclear, but several phylogenetic observations suggest that it is a crucial component in the development of myelin as a multi-lamellar membrane structure. Sharks, which appeared in the fossil record about 400 million years ago, are the first fully myelinated organisms. In this study we investigated the expression pattern of shark myelin Po to suggest a way it might have played a role in the evolution of myelin in the central nervous system. We found that sharks have more than two isoforms (32, 28 and 25 kD), and that some of these might not be fully functional because they lack the domains known for Po homophilic adhesion.
