ABSTRACT
No disponible
Subject(s)
Humans , Fibromyalgia/complications , Fibromyalgia/diagnosis , Fibromyalgia/therapyABSTRACT
No disponible
Subject(s)
Humans , Fibromyalgia/etiology , Sleep Wake Disorders/etiology , Depression/etiology , Paresthesia/etiology , Substance P/pharmacology , Selective Serotonin Reuptake Inhibitors/pharmacology , Fibromyalgia/complications , Fibromyalgia/drug therapy , Autonomic Nervous System Diseases/etiology , Life Style , DrinkingSubject(s)
Arthritis , Arthropathy, Neurogenic , Hand Deformities, Acquired , Occupational Diseases , HumansABSTRACT
Cutaneous immunofluorescence studies were carried out in 21 patients with ankylosing spondylitis (AS) and the results compared with those for 18 healthy subjects. The most prominent finding was the presence of IgA in dermal vessels of patients with AS (71% compared with 17% of the control group). IgG and IgM cutaneous deposits were also observed in patients with AS, but these results did not differ from those of the control group. A renal biopsy was performed in three of the patients presenting with unexplained microscopic haematuria. One of them had an IgA nephropathy, but no correlation was found between kidney and skin deposits of IgA. These findings suggest that IgA cutaneous deposits in AS are not a marker of IgA nephropathy but stress the role of immunoglobulin A in the pathogenesis of this disease.
Subject(s)
Immunoglobulin A/analysis , Skin/immunology , Spondylitis, Ankylosing/immunology , Adult , Female , Fluorescent Antibody Technique , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/immunology , Humans , Male , Spondylitis, Ankylosing/complicationsABSTRACT
We studied the clinical, scintigraphic, and histopathologic characteristics of 26 intravenous drug abusers with costochondral involvement secondary to systemic infection with Candida albicans. The clinical findings were of a mass appearing in the anterior region of the thorax. In general, signs of inflammation were absent. Histopathologic study of this costochondral mass in 12 patients showed perichondritis in 100% and myositis in 87%, with secondary involvement of cartilage in 43% and of bone in 75%. Results of bone scintigrams using 99mTc-methylene diphosphonate were positive in only 7 of 15 patients (47%), with a correlation between positive uptake and osteitis. Gallium scintigraphy findings were positive in 9 of 10 patients (90%). The greater sensitivity of 67Ga was probably because the invariably present pericartilaginous inflammatory mass was not always accompanied by secondary cartilage and bone involvement.
Subject(s)
Candidiasis/etiology , Cartilage/pathology , Heroin , Ribs/pathology , Substance-Related Disorders/complications , Adolescent , Adult , Candida albicans/isolation & purification , Candidiasis/diagnostic imaging , Candidiasis/pathology , Cartilage/diagnostic imaging , Cartilage/microbiology , Female , Humans , Male , Ribs/diagnostic imaging , Ribs/microbiology , Syndrome , Tomography, Emission-ComputedSubject(s)
Glomerulonephritis, IGA/complications , Spondylitis, Ankylosing/complications , Adult , Female , HumansSubject(s)
Arthritis/pathology , Acute Disease , Adult , Aged , Aged, 80 and over , Arthritis/etiology , Arthritis/metabolism , Calcinosis , Calcium Pyrophosphate/analysis , Crystallization , Female , Gout/complications , Humans , Inpatients , Male , Middle Aged , Prospective Studies , Uric Acid/analysisSubject(s)
C-Reactive Protein/analysis , Immunoglobulin A/analysis , Spondylitis, Ankylosing/immunology , Adolescent , Adult , Female , Humans , Male , Middle AgedABSTRACT
Fifty one patients with ankylosing spondylitis (AS) were typed for HLA-A, B, C, DR, and DQ antigens. The antigen frequencies were compared with those of a normal population and with a B27 positive control group. All but one of the patients with AS were HLA-B27 positive. A positive linkage disequilibrium between Cw1, Cw2, DR1, and the B27 antigen was observed. Patients with AS showed a significant increase in DQw2 antigen compared with the B27 positive control group. No differences in antigenic frequencies were observed in patients having peripheral arthritis and patients with only axial involvement. Seven out of nine patients (78%) with an erosive peripheral arthritis were DR7 positive, suggesting that DR7 or genes closely linked could be related with a more aggressive peripheral joint involvement in patients with AS.
Subject(s)
Arthritis/immunology , HLA-D Antigens/analysis , HLA-DQ Antigens/analysis , HLA-DR Antigens/analysis , Spondylitis, Ankylosing/immunology , Arthritis/complications , Female , HLA Antigens/analysis , Histocompatibility Testing , Humans , Male , Spondylitis, Ankylosing/complicationsSubject(s)
Arthritis/therapy , Activities of Daily Living , Arthritis/etiology , Female , Humans , Male , Occupations , Patient Education as Topic , PostureABSTRACT
Seven patients (five male and two female) with chronic renal failure (CRF) treated by periodical haemodialysis presented with swelling and effusion of more than three months' duration in knees (four bilateral), shoulders (two, one of them bilateral), elbow (one), and ankle (one). Four had a carpal tunnel syndrome both clinically and electromyographically (three bilateral). All patients had hyperparathyroidism secondary to their CRF, which was not due to amyloidosis in any of them. The dialysis duration period varied from five to 14 years, with an average of 8.6 years. Amyloid deposits (Congo red positive areas with green birefringence under polarising microscopy) were shown in six of the seven synovial biopsy specimens of the knee, in five of the sediments of the synovial fluids, and in specimens removed during carpal tunnel syndrome surgery. No amyloid was found in the biopsy specimen of abdominal fat of six of the patients. The finding of amyloid only in the synovial membrane and fluid, and carpal tunnel, its absence in abdominal fat, and the lack of other manifestations of generalised amyloidosis (cardiomyopathy, malabsorption syndrome, macroglossia, etc.) and of Bence Jones myeloma (protein immunoelectrophoresis normal) raises the possibility that this is a form of amyloidosis which is peculiar to CRF treated by periodical haemodialysis.
Subject(s)
Amyloidosis/etiology , Kidney Failure, Chronic/complications , Renal Dialysis , Synovitis/etiology , Adult , Amyloid/analysis , Amyloidosis/metabolism , Carpal Tunnel Syndrome/etiology , Female , Humans , Kidney Failure, Chronic/therapy , Male , Middle Aged , Synovial Fluid/analysis , Synovial Membrane/analysis , Synovitis/metabolismSubject(s)
Arthritis, Infectious/diagnosis , Chondrocalcinosis/diagnosis , Aged , Diagnosis, Differential , Female , Humans , MaleABSTRACT
A patient with longstanding ankylosing spondylitis (AS) developed a cauda equina syndrome. The myelogram showed a block at the L2 level. Vertebral computerised tomography showed calcification in the centre of the spinal canal. The patient also had features suggestive of a diffuse idiopathic skeletal hyperostosis (DISH). Meningeal calcification has never been reported in AS, so we suggest that this is related to an associated DISH. Cauda equina syndrome has not been described in DISH, and calcification of meninges has not been reported in AS, so we suggest that the meningeal calcifications and associated cauda equina syndrome are related to DISH.
