ABSTRACT
Laser tattoo removal is expensive, painful, and time-consuming. Even with the use of the right laser equipment, it is often impossible to eliminate all pigments. Incomplete tattoo removal, one of the undesired effects of laser treatment, is widely disseminated in the media and accepted by most patients. However, few patients know that laser tattoo removal can cause permanent scars. Some patients who develop achromic scars can feel disappointed with the results of laser tattoo removal and take legal action against the physician responsible for the treatment. This paper describes our experience with a drug delivery treatment called MMP® ("Microinfusão de Medicamentos na Pele," Portuguese acronym for "Microinfusion of Drugs in the Skin") that repigments and improves the final esthetic results of achromic laser tattoo removal scars.
ABSTRACT
BACKGROUND: Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. OBJECTIVE: Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. METHODS: Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. RESULTS: In drug delivery done on human skin using a liquid with a density of 1,271,460 µg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm2 , and a needling depth of 300 microns, we estimate that 1,175 µg/cm2 were delivered (standard deviation 601 µg/cm2 , standard error 190 µg/cm2 ). LIMITATIONS: This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. CONCLUSION: The MMP drug delivery technique injects small amounts of medication (1,175 µg/cm2 ) homogeneously into the dermis.
Subject(s)
Dermatologic Agents/administration & dosage , Drug Delivery Systems/instrumentation , Tattooing/instrumentation , Drug Delivery Systems/methods , Humans , Injections, Subcutaneous/instrumentation , Injections, Subcutaneous/methods , Skin , Skin Absorption , Tattooing/methodsABSTRACT
Medicações sistêmicas orais como ciclosporina (CYA) ou metotrexato (MTX) para tratamento de psoríase tem biodisponibilidade limitada devido à absorção incompleta gastrointestinal e metabolização de primeira passagem hepática. Além disso, estão associados a efeitos adversos. A aplicação de CYA ou MTX através da Microinfusão de Medicamentos pela pele (MMP®) para tratamento de psoríase vulgar mostrou resposta terapêutica com redução significativa de lesões, sem indução de efeitos colaterais. Neste relato, descrevemos 4 casos de psoríase vulgar tratados com MMP® com CYA ou MTX.
Systemic oral medications such as cyclosporine (CYA) or methotrexate (MTX) for the treatment of psoriasis have limited bioavailability due to incomplete gastrointestinal absorption and first-pass hepatic metabolism. Moreover, they are associated with adverse effects. The application of CYA or MTX using the microinfusion of drugs into the skin method (MMP®) for the treatment of psoriasis vulgaris yielded a therapeutic response with significant reduction of lesions, and absence of side effects. In the present report, the authors describe 4 cases of psoriasis vulgaris treated using the MMP® method, with the application of CYA or MTX.
ABSTRACT
Introdução: A fração vascular estromal derivada do tecido adiposo é fonte rica de diferentes células, contendo grande população de células-tronco, que tem capacidade de diferenciação para diversas linhagens. Em dermatologia, há diversos estudos sobre a eficácia das células-tronco, que apresentam ação antioxidante e efeitos no rejuvenescimento. No entanto, ainda são poucos os relatos sobre os efeitos antienvelhecimento da fração vascular estromal. Objetivo: Avaliar a efetividade da fração vascular estromal no rejuvenescimento facial. Métodos: Estudo prospectivo, comparativo e controlado, com 10 pacientes divididos em dois grupos e submetidos a tratamento do sulco nasogeniano com: Grupo 1: fração vascular estromal e Grupo 2: preenchedor convencional: hidroxiapatita de cálcio. Foram realizadas avaliações clínica, fotográfica e histológica com análise estatística dos dados. Resultado: Ambas as técnicas produziram resultados satisfatórios e semelhantes. Conclusões: A aplicação da fração vascular estromal é técnica relativamente nova que apresenta bons resultados clínicos, sendo opção promissora para o rejuvenescimento.
Introduction: Stromal vascular fraction derived from adipose tissue is a rich source of different cells, containing large amounts of stem cells, which ability for diferentiation into various strains. In dermatology, there are several studies on the effectiveness of stem cells, which present antioxidant and rejuvenating effects. However, there are few reports about the anti-aging effects of stromal vascular fraction. Objective: To evaluate the effectiveness of stromal vascular fraction in facial rejuvenation. Methods: A prospective, comparative, controlled study was carried out, wit, with 10 patients divided into two groups and subjected to treatment of nasolabial folds with: Group 1: stromal vascular fraction and Group 2: conventional filler (calcium hydroxyapatite). Clinical, photographic and histological evaluations were conducted, with statistical analysis of data. Results: Both techniques produced satisfactory results and were similar. Conclusion: Application of stromal vascular fraction is a relatively new technique that presents good clinical results and is a promising option for rejuvenation.
ABSTRACT
Os autores relatam um caso típico de sífilis secundária em paciente do sexo feminino, cujas manifestaçöes dermatológicas se apresentaram sob a forma de lesöes eritematosas anulares e pápulas liquenóides localizadas na regiäo vulvar, suprapúbica e face, lesöes anulares de aspecto rupióide na regiäo lombossacra e pápulas lenticulares de coloraçäo acobreada com colarete descamativo nas bordas, dispostas bilateralmente nas palmas das mäos e pés. O dorso da língua apresentava lesöes enantemato-esbranquiçadas de configuraçäo anular. O diagnóstico clínico foi confirmado com reaçöes sorológicas para sífilis positivas e exame anti-HIV (ELISA) negativo. A paciente foi tratada com penicilina benzatina havendo regressäo completa das manifestaçöes cutâneo-mucosas.
