ABSTRACT
Two optically active liquid anion-exchangers have been synthesized. The separation factors of the enantiomers of sodium (+/-)-mandelate and sodium-N-acetyl-(+/-)-alanate have been determined by batchwise equilibration of aqueous solutions of the salts with chloroform solutions of each of the exchangers. Sodium mandelate has been resolved by Craig countercurrent extraction with one of these exchangers. Optically pure products can be obtained even though the liquid ion-exchanger is not optically pure.
ABSTRACT
The racemic alcohols, 2-methylbutanol-l, 3-methylbutanol-2, pentanol-2 and hexanol-2 have been esterified with optically active mandelic or lactic acid, and the resultant mixtures of diastereoisomeric esters separated chromatographically with an optically inactive sulphonated polystyrene resin as the stationary phase and water or dilute aqueous sodium sulphate as the mobile phase. Lactate esters were more easily separated than mandelate esters. The Chromatographic separation of 26 mmole of (+/-)-3-methyl-2-butyl(+)-lactate and subsequent hydrolysis of the fractions containing only the ester of the (+)-alcohol yielded 1-2 mmole of pure 3-methyl-2-butanol.
