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3.
Dtsch Med Wochenschr ; 105(29): 1015-8, 1980 Jul 18.
Article in German | MEDLINE | ID: mdl-7408700

ABSTRACT

L-Thyroxine was given to 3956 patients with benign goitre between 1974 and 1977, 2314 of which were controlled over a period of 3 years at regular intervals. Benign goitre in children less than 14 years old and postoperative recurrences were not evaluated. Definite reduction in goitre size wss achieved in 77.2% of patients by continuous long-term treatment over 3 years. In large goitres and those with nodular transformation the status quo was maintained in all but exceptional cases.


Subject(s)
Goiter/drug therapy , Thyroxine/therapeutic use , Female , Goiter/surgery , Humans , Male , Recurrence , Thyroxine/administration & dosage , Time Factors
8.
J Pediatr ; 86(5): 753-8, 1975 May.
Article in English | MEDLINE | ID: mdl-48542

ABSTRACT

Eighty-four term newborn infants without goiter and 45 newborn infants with congenital goiter were studied with regard to thyroid function. The radiologic development of the femoral and tibial epiphyses was evaluated in those with goiter. Fifty-eight percent of the patients had retarded bone age, markedly elevated TSH levels, elevated TBI, decreased total T4I, and decreased PBI values. Forty-two percent of newborn infants with congenital goiter had a normal bone age, normal values for TSH, PBI, and total T4I, and elevated values for TBI. It is concluded that the 58% of the newborn infants with congenital goiter had subtle hypothyroidism. They require substitution therapy with thyroid hormones in order to avoid possible retardation of normal brain development. Patients with congenital goiter who have no biochemical evidence of hypothyroidism should also be treated with thyroid hormones to achieve rapid regression of goiter.


Subject(s)
Goiter/congenital , Infant, Newborn, Diseases/physiopathology , Thyroid Gland/physiopathology , Bone Development , Goiter/physiopathology , Humans , Infant, Newborn , Thyroid Function Tests , Thyrotropin/blood , Thyroxine/blood , Thyroxine-Binding Proteins/analysis , Triiodothyronine/blood
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