ABSTRACT
Results of clinico-morphological and immunohistochemical studies of 44 cases of carcinosarcoma of the uterus are presented in an attempt to provide pathogenetic rationale for prognosticators of the disease. Immunohistochemical reactions were used to evaluate the expression of genes and mediators p53 and PTEN and cyclooxigenase (COX-2) in cells of mesenchyme and epithelium of tumor to gauge the influence of either component on its biological behavior. All patients were divided into two groups depending on whether they revealed expression of p53, PTEN and cyclooxigenase or not. The end results--overall survival and complete remission duration--were compared in both groups. No dominance of either component of carcinosarcoma was established.
Subject(s)
Biomarkers, Tumor/analysis , Carcinosarcoma/chemistry , Uterine Neoplasms/chemistry , Adolescent , Adult , Aged , Carcinosarcoma/mortality , Carcinosarcoma/pathology , Cyclooxygenase 2/analysis , Disease-Free Survival , Female , Humans , Immunohistochemistry , Middle Aged , PTEN Phosphohydrolase/analysis , Survival Analysis , Tumor Suppressor Protein p53/analysis , Uterine Neoplasms/mortality , Uterine Neoplasms/pathology , Young AdultABSTRACT
The results of treatment of 443 patients with endometrial carcinoma (surgery--101 (22.8%), combined therapy--183 (41.3%) and complex therapy--159 (35.9%) are presented. The role of clinico-morphological factors, including steroid hormone receptor levels in tumor, is discussed with a view to combat tumor.
Subject(s)
Adenocarcinoma/therapy , Uterine Neoplasms/therapy , Adenocarcinoma/mortality , Adenocarcinoma/radiotherapy , Adenocarcinoma/surgery , Age Factors , Combined Modality Therapy , Data Interpretation, Statistical , Evaluation Studies as Topic , Female , Follow-Up Studies , Humans , Middle Aged , Progestins/therapeutic use , Time Factors , Uterine Neoplasms/mortality , Uterine Neoplasms/radiotherapy , Uterine Neoplasms/surgerySubject(s)
Leukemia, Myeloid, Acute/mortality , Mathematical Computing , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Disease-Free Survival , Female , Humans , Infant , Leukemia, Myeloid, Acute/pathology , Leukemia, Myeloid, Acute/therapy , Male , Remission Induction , Retrospective Studies , Survival RateABSTRACT
The study of morphological and biological criteria of laryngeal squamous cell carcinoma in 81 patients proved essential in the disease prognosis. In grade I malignancy 90 +/- 6.7% of patients were 3 years free of recurrences and metastases, in grade 11 - 76 +/- 8.6%, in grade III - 50 +/- 15.8%. Aneuploid laryngeal tumors produced recurrences 6 times more frequently than diploid ones. 3-year recurrence--and metastases-free survival was reported in 88.7 +/- 6.3% of patients with diploid and 59.3 +/- 7.7%. 7% with aneuploid tumors (p < 0.05).
