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Bioorg Med Chem Lett
; 11(9): 1211-3, 2001 May 07.
Article
in English
| MEDLINE
| ID: mdl-11354379
ABSTRACT
A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone la. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50 = 3 nM) and 4-(naphth-2-yloxy)phenyl (4h, IC50 = 4 nM) as P1' groups.