Total Lip Reconstruction after Excision of Cancer with Composite Radial Forearm Palmaris Longus Tendon Free Flap.

Reconstruction of total lip is a challenging task for a plastic surgeon. It becomes more complicated when there is loss of additional tissues like angle of mouth, buccal mucosa or floor of the mouth. Radial forearm flap with palmaris longus tendon provides an easier but reliable technique for three dimensional lip reconstructions with good functional and aesthetic outcome. In this short observational series we included 5 patients of total lip reconstruction and conducted at Sylhet MAG Osmani Medical College Hospital and Private Clinic of Sylhet, Bangladesh from January 2014 to December 2017. Among these one was a case of basal cell carcinoma of upper lip and rest was squamous cell carcinoma of lower lip. The mean age was 71 years. All the flaps survived and patients had normal speech and oral continence. Composite radial forearm flap with palmaris longus tendon is a good, reliable option for total lip reconstruction.

Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice.

The methanol extract of the leaves of Pandanus foetidus Roxb. (Pandanaceae) was assessed for neuropharmacological activities in mice using a number of experimental models. The extract dose-dependently inhibited acetic acid-induced writhing in mice when given at the doses of 250 and 500 mg/kg body weight. At the same dose levels, it significantly prolonged the pentobarbitone-induced sleeping time in mice, and showed mild to moderate central nervous system depressant activity when assessed by the hole cross and the open field tests in mice model. On the basis of these findings, it can be assumed that the extract exerts its depressant effect on the central nervous system in mice by interfering with the cortical function.

Propiedades antidiarreicas de Diospyros peregrina en el modelo de diarrea inducida con aceite de ricino en ratones / Anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhoea model in mice

Diospyros peregrina (Gruke), de la familia de las ebenáceas, posee varias propiedades medicinales y se utiliza enla medicina tradicional de Bangladesh. En este estudio se investigaron los extractos de metanol de la corteza y lassemillas de esta planta en el modelo de diarrea inducida con aceite de ricino en ratones. También se estudiaronlas propiedades antibacterianas de los extractos frente a varias bacterias patógenas causantes de diarrea y disenteríamediante el método de difusión en disco. Con una dosis de 250 y 500 mg/kg de peso corporal, los extractosretrasaron la aparición de la diarrea. Los extractos también redujeron la frecuencia y la gravedad de la diarrea enlos animales de los grupos de prueba durante todo el período de estudio. A igual dosis, los extractos retrasaron eltránsito intestinal del preparado de carbón en los animales del grupo de prueba en comparación con los del grupode control, y los resultados fueron signifi cativos estadísticamente. En ambos casos, el extracto de semilla resultó máspotente que el extracto de corteza. El extracto de corteza inhibió el crecimiento de Staphylococcus aureus, Shigelladysentery, Escherichia coli y Pseudomonas aeruginosa, mientras que el extracto de semilla demostró poseer actividadinhibitoria frente a S. aureus, S. dysentery y E. coli

Diospyros peregrina Gruke. (Ebenaceae) possesses a number of medicinal properties, and is used in Bangladeshi traditional ;;medicine. In this study, the methanol extracts of the barks and seeds of this plant have been investigated in ;;the castor oil induced diarrhoea model in mice. The extracts were also studied for their anti-bacterial properties by ;;disc diffusion method against a number of pathogenic bacteria responsible for causing diarrhoea and dysentery. At ;;the doses of 250 and 500 mg/kg body weight, the extracts delayed the onset of diarrhoea. The extracts also reduced the ;;frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts delayed ;;the intestinal transit of charcoal meal in test animals as compared to the control, and the results were statistically signifi ;;cant. In both cases the seed extract was found to be more potent than the bark extract. The bark extract inhibited ;;the growth of Staphylococcus aureus, Shigella dysentery, Escherichia coli and Pseudomonas aeruginosa, whereas the ;;seed extract demonstrated inhibitory activity against S. aureus, S. dysentery and E. coli

Antinociceptive activity of Ceriops decandra leaf and pneumatophore.

The ethanol extract of Ceriops decandra leaf and pneumatophore, at the oral doses of 250 and 500 mg/kg, showed a dose-dependent and significant inhibition of acetic acid-induced writhing in mice. On the contrary, the bark extract was devoid of any significant activity.