Subject(s)
COVID-19/complications , Neoplasms/complications , Adolescent , Algeria/epidemiology , COVID-19/epidemiology , COVID-19/mortality , Cancer Care Facilities , Child , Child, Preschool , Female , Humans , Infant , Male , Neoplasms/epidemiology , Neoplasms/mortality , Risk Factors , SARS-CoV-2/isolation & purificationABSTRACT
Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome t (9;22) and the BCR-ABL fusion gene. The condition is relatively rare, accounting for 2.0% to 3.0% of childhood leukemia cases. CML has historically been a triphasic disease. Most patients are diagnosed in chronic phase. Without treatment, it inevitably progresses into a more aggressive accelerated phase and blast crisis. Some proportion of CML cases of blastic transformation develop an extramedullary disease that involves rarely central nervous system. This report describe an extremely rare case of 13-year-old girl with CML and extramedullary blast crisis in the central nervous system. Treatment options and monitoring of disease response are discussed.
