ABSTRACT
Numerous oral manifestations associated with salivary gland dysfunction, and particularly Sjögren's syndrome, have been reported in the literature. This article discusses the evidence on a wide range of oral manifestations associated with Sjögren's syndrome.
Subject(s)
Sjogren's Syndrome/complications , Candidiasis, Oral/etiology , Deglutition Disorders/etiology , Facial Pain/etiology , Gastroesophageal Reflux/etiology , Humans , Mouth Mucosa/injuries , Periodontal Diseases/etiology , Tooth Diseases/etiologySubject(s)
Mouth/physiopathology , Oral Submucous Fibrosis/pathology , Oral Submucous Fibrosis/physiopathology , Adult , Antioxidants/therapeutic use , Areca/adverse effects , Carotenoids/therapeutic use , Diagnosis, Differential , Female , Humans , Lycopene , Masticatory Muscles/physiopathology , Mouth Mucosa/pathology , Myofunctional Therapy , Oral Submucous Fibrosis/etiology , Range of Motion, ArticularABSTRACT
PURPOSE: Dysphagia (swallowing dysfunction) is a debilitating, depressing, and potentially life-threatening complication in cancer patients that is likely underreported. The present paper is aimed to review relevant dysphagia literature between 1990 and 2010 with a focus on assessment tools, prevalence, complications, and impact on quality of life in patients with a variety of different cancers, particularly in those treated with curative chemoradiation for head and neck cancer. METHODS: The literature search was limited to the English language and included both MEDLINE/PubMed and EMBASE. The search focused on papers reporting dysphagia as a side effect of cancer and cancer therapy. We identified relevant literature through the primary literature search and by articles identified in references. RESULTS: A wide range of assessment tools for dysphagia was identified. Dysphagia is related to a number of factors such as direct impact of the tumor, cancer resection, chemotherapy, and radiotherapy and to newer therapies such as epidermal growth factor receptor inhibitors. Concomitant oral complications such as xerostomia may exacerbate subjective dysphagia. Most literature focuses on head and neck cancer, but dysphagia is also common in other types of cancer. CONCLUSIONS: Swallowing impairment is a clinically relevant acute and long-term complication in patients with a wide variety of cancers. More prospective studies on the course of dysphagia and impact on quality of life from baseline to long-term follow-up after various treatment modalities, including targeted therapies, are needed.
Subject(s)
Deglutition Disorders/diagnosis , Deglutition Disorders/epidemiology , Neoplasms/epidemiology , Antineoplastic Agents/adverse effects , Causality , Chemoradiotherapy/adverse effects , Chemoradiotherapy/statistics & numerical data , Comorbidity , Deglutition Disorders/physiopathology , ErbB Receptors/antagonists & inhibitors , Head and Neck Neoplasms/epidemiology , Head and Neck Neoplasms/surgery , Humans , Neoplasms/surgery , Postoperative Complications/epidemiology , Prevalence , Quality of Life , Xerostomia/epidemiologyABSTRACT
OBJECTIVES: The aims of this study were to evaluate the prevalence of oral burning in a dry mouth cohort of patients and to determine associated factors. STUDY DESIGN: A retrospective cohort study was conducted by reviewing the charts of 170 patients who presented to Carolinas Medical Center's Department of Oral Medicine from January 2004 to June 2009. Information collected from their charts was extensive. RESULTS: Forty percent (68 of 170) of dry mouth patients had a concomitant complaint of oral burning. Sixty-four were female and 4 were male. The mean age was 61.1 years (range 25-89). Cofactors associated with oral burning included age (OR 1.03, CI 1.00-1.05, P = .028) and use of herbal medications (OR .26, CI .10-.67, P = .005). CONCLUSIONS: Oral burning is often concomitant with oral dryness. Targeting factors associated with oral dryness may help alleviate an oral burning complaint in select populations.
