ABSTRACT
We report the first case of brucellosis caused by an isolate whose genome is identical that of a frog isolate from Texas, demonstrating the zoonotic potential of amphibian-type Brucella. Importantly, with such atypical Brucella, correct diagnosis cannot be performed using routine serological tests or identification methods.
Subject(s)
Brucella , Brucellosis , Amphibians , Animals , Brucella/genetics , Brucellosis/diagnosis , Humans , Serologic Tests , TexasABSTRACT
We report the case of a 79-year-old patient, admitted to the department of infectious diseases at Bretagne Sud Hospital Center for a right calcaneal osteitis, complicated by a pacemaker leads infectious endocarditis. Meticillin sensitive Staphylococcus aureus was documented by blood culture. Antibiotic treatment was established using intravenous cefazolin for an initial 6 weeks period. Prothrombin time (PT) decreased as well as vitamin K dependent factors, without anticoagulation therapy, at day 7 of cefazolin treatment. After bleeding occurred on calcaneal osteitis, the VAC® therapy system was removed and intravenous vitamin K 10 mg (then 5 mg per day for 5 days per os) was administered. Vitamin K allowed PT and vitamin K dependent factors to return to normal values. Literature review does not explicitly mention the effects on vitamin K dependent factors after cefazolin administration. Four severe haemorrhagic episodes under cefazolin have been declared in France so far since February 2017. The goal of this article is to alert clinicians and clinical pathologists from the potential appearance of coagulation disorders in patients treated by cefazolin.
Subject(s)
Blood Coagulation Disorders/chemically induced , Cefazolin/adverse effects , Sepsis/drug therapy , Staphylococcal Infections/drug therapy , Aged , Blood Coagulation Disorders/diagnosis , Drug Substitution , Hemorrhage/chemically induced , Humans , Male , Pacemaker, Artificial/microbiology , Penicillins/therapeutic use , Prosthesis-Related Infections/complications , Prosthesis-Related Infections/drug therapy , Sepsis/complications , Sepsis/microbiology , Staphylococcal Infections/complicationsABSTRACT
We report a case of meningitis due to Streptococcus australis, a species of oral streptococcus. Accurate identification was performed by various molecular techniques.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Meningitis, Bacterial/microbiology , Streptococcal Infections/microbiology , Streptococcus/immunology , Aged , Bacterial Proteins/chemistry , Bacterial Proteins/genetics , Base Sequence , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , Humans , Male , Meningitis, Bacterial/cerebrospinal fluid , Meningitis, Bacterial/drug therapy , Meningitis, Bacterial/immunology , Microbial Sensitivity Tests , Molecular Sequence Data , Polymerase Chain Reaction , RNA, Ribosomal, 16S/chemistry , RNA, Ribosomal, 16S/genetics , Sequence Analysis, DNA , Streptococcal Infections/cerebrospinal fluid , Streptococcal Infections/drug therapy , Streptococcal Infections/immunology , Streptococcus/genetics , Superoxide Dismutase/chemistry , Superoxide Dismutase/geneticsABSTRACT
Three patients with extensive necrotizing pneumonia due to Panton-Valentine leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3x10(9)/liter in all three cases and hemoptysis in two cases) were successfully treated with toxin-suppressing agents introduced rapidly after hospital admission.
