ABSTRACT
This case report describes a 53-year-old man with multiple erythematous macules and papules diffusely distributed on the frontal area, cheeks, eyelids, nose, and supralabial skin.
Subject(s)
Arteriovenous Malformations , Capillaries/abnormalities , Port-Wine Stain , Humans , Arteriovenous Malformations/diagnosis , Port-Wine Stain/diagnosisABSTRACT
ABSTRACT: An 84-year-old woman presented with a 3-month history of a papular rash on the trunk, abdomen, and back. Histopathological examination revealed atypical lymphoid deep and band-like dermal infiltrates with marked epidermotropism. Neoplastic cells expressed B-cell markers (CD20), and clonal immunoglobulin gene rearrangement was observed. A complete peripheral blood study revealed aberrant circulating villous lymphocytes with the expression of B-cell markers (CD20, CD22, and CD79a) and aberrant expression of CD5. A staging workup revealed discrete splenic enlargement and bone marrow and gastrointestinal tract involvement. Skin lesions regressed spontaneously several weeks after diagnosis. Throughout evolution, the patient developed scattered cutaneous nodules and generalized papulo-nodules showing either epidermotropic or nonepidermotropic atypical dermal lymphoid infiltrates. This case illustrates the observation of autoinvolutive and recurrent epidermotropic B-cell atypical cutaneous infiltrates as a characteristic feature of secondary cutaneous involvement in splenic marginal B-cell lymphoma. Previously reported cases of epidermotropic B-cell lymphoma have been reviewed. Concurrent and simultaneous observation of epidermotropic and nonepidermotropic lesions seems to indicate that epidermotropism is an important but nonconstant diagnostic feature of splenic marginal B-cell lymphoma.
Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell , Lymphoma, B-Cell, Marginal Zone , Skin Diseases , Skin Neoplasms , Female , Humans , Aged, 80 and over , Lymphoma, B-Cell, Marginal Zone/pathology , Skin/pathology , Skin Neoplasms/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Skin Diseases/pathologyABSTRACT
The typical finding in secondary syphilis stage is a generalized non-pruritic maculopapular eruption. We report a case of secondary syphilis in an HIV-infected patient presenting with pruritic crusted nodules showing numerous eosinophils on the histopathological examination.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Penicillin G Benzathine/administration & dosage , Syphilis, Cutaneous/pathology , Syphilis/drug therapy , Treponema pallidum/isolation & purification , Exanthema , HIV Infections/drug therapy , Humans , Injections, Intramuscular , Male , Middle Aged , Penicillin G Benzathine/therapeutic use , Syphilis/pathology , Syphilis, Cutaneous/drug therapy , Treatment Outcome , Treponema pallidum/immunologyABSTRACT
The typical finding in primary syphilis stage is a unique, painless chancre with indurated borders. We report a case of primary syphilis presenting as erosive and crusted balanoposthitis with an underlying chancre, penile edema, and bilateral inguinal lymphadenopathy in a heterosexual man.
