Conformational Equilibrium of Cinchonidine in C6D12 Solution. Alternative NMR/DFT Approach.

1H NMR and 13C NMR chemical shifts as well as conformation dependent vicinal 1H-1H spin-spin coupling constants for cinchonidine in a dilute C6D12 solution have been measured. These data have been interpreted in detail exploiting the results of the extensive quantum chemistry calculations of molecular geometry and NMR parameters of the molecule, performed using the density functional theory (DFT) B3LYP/6-311++G(2d,p) polarizable continuum model (PCM) level of theory. The experimental values of NMR parameters for cinchonidine have been reproduced very well in terms of parameters calculated for key conformers of this molecule. Simultaneously, the analysis has provided us with a lot of information on conformational equilibrium of cinchonidine in the investigated solution. These findings remain in general agreement with the conclusions of other works, based on NOESY spectra or other physicochemical data. Thus, a careful quantitative interpretation of easily measurable NMR chemical shifts can be an independent and valuable source of structural information even in such complex cases as cinchonidine in solution.

[1,4]-sigmatropic rearrangement of chiral nitrones and their utilization in the synthesis of new iminosugars.

Reflection on the epimerization of the α-stereocenter of sugar nitrones leads to the conclusion that the process may occur through [1,4]-sigmatropic rearrangement. Participation of an ionic mechanism was excluded by a deuterium labeling experiment, and DFT calculations showed a reasonable energy barrier for the proposed [1,4]-shift. Products of the intramolecular 1,3-dipolar cycloaddition of the studied nitrones were utilized in the diversity-oriented synthesis of polyhydroxy derivatives of piperidine, indolizidine and quinolizidine. Minimal activity against the screened glucosidases and human melanoma cell lines was observed for some of the obtained compounds.

Massive myiasis in an advanced metastatic neck tumor.

Only a small number of cases of myiasis have been previously reported in patients with a head and neck malignancy; most of these occurred in patients with primary or metastatic skin cancer. We report a case of massive Lucilia sericata myiasis in the neck of a 57-year-old man with primary squamous cell carcinoma of the larynx and hypopharynx that metastasized to the neck lymph nodes. The neck disease manifested as necrosis and skin involvement. Clinical examination revealed an extensive wound within the neck tumor at levels II and V on the right that was heavily infested with maggot larvae. Removal of larvae clusters was performed, and the isolated larvae were subsequently identified as L sericata. To the best of our knowledge, this is the first report of an infestation of L sericata myiasis in a metastasis to the neck lymph nodes.

[Cat scratch disease--a diagnostic problem, case report]. / Choroba kociego pazura--problem diagnostyczny, opis przypadku.

AIM OF THE STUDY: Cat scratch disease as a possible cause of neck limphadenopathy. MATERIAL AND METHODS: We present a case of 40-years old men operated in our department on regional unilateral lymphadenopathy. The diagnosis of cat scratch disease was confirmed by the histopathologic examination. CONCLUSIONS: Regional lymphadenopathy with history of contact with cats or other animals suggests the diagnosis of cat scratch disease. If we considered this disease in differential diagnosis it would mean less traumatic treatment for the patient. Cat scratch disease is diagnosed in Poland very rarely; we need to spread the knowledge about this infectious disease.

[Differential diagnosis and treatment of neck masses. A study based on observation in Otolaryngology Department of Miedzyleski Specialistic Hospital in Warsaw]. / Diagnostyka róznicowa i leczenie guzów szyi w materiale oddzialu Otolaryngologii Miedzyleskiego Szpitala Specjalistycznego w Warszawie.

In otolaryngology practice we quite often encounter neck masses in all age group patients. The differential diagnosis is extensive and represents a variety of pathologic conditions of various origins, especially in relation to patient age. The authors present a retrospective analysis of patients with a neck mass treated in Otolaryngology Department of Miedzyleski Specialistic Hospital in Warsaw over the period of two years. Patients were divided into groups according to their age. Within each group the incidence of congenital, inflammatory and neoplastic disease was assessed. The most numerous was the group of adults older than 40 years of age with the highest incidence of malignant neoplasms. The location of metastatic lymph nodes in relation to primary site was described. Finally, methods of management for each tumour type were presented. Then we discuss a work-up of a neck mass with regard to literature data.

[Unusual pathology of submandibular gland--Küttner tumor]. / Rzadka patologia slinianki podzuchwowej--guz Küttnera.

Küttner tumor (chronic sclerosing sialadenitis) is a chronic, benign lesion of salivary gland. Its clinical course resamble malignant process. Authors report two typical cases of CSS affecting submandibular gland. We inform, that we start follow up of those cases consist of--us imaging /twice a year/, indication of LE and IgG level, protein electrophoresis.

[Facelift incision parotidectomy: preliminary report]. / Parotidektomia z dostepu do liftingu twarzy--doniesienie wstepne.

INTRODUCTION: Traditional approaches parotidectomy leaves a visible scar and a hollow on the face and neck, which might be dissappointing to some patients. AIM OF THE STUDY: Assessment of usefulness of facelift approach to the parotid gland PATIENT AND METHODS: A retrospective study was performed. In June 2009 eight patients with benign parotid tumour underwent superficial parotidectomy. Four of them were included in the rhytidectomy approach parotidectomies and SMAS advancement flap was carried out to reconstruct the parotid bed and prevent Frey's syndrome. The latter patients underwent the classical technique parotidectomies. After two months from the operation both groups of patients were asked to assess the cosmetic outcome of the surgery in five degree scale. RESULTS: The duration of the operation increased by an average of 20 minutes in the rhytidectomy approach group. No major difficulties in exposing the facial nerve and its branches were observed. Patients were more satisfied when facelift approach was performed. CONCLUSION: A rhytidectomy approach to the parotid gland seems to be safe method and aesthetic results are more satisfactory as comparing to classical approach.

[A rare case of cerebrospinal fluid rhinorrhea]. / Rzadki przypadek plynotoku nosowego.

INTRODUCTION: Cerebrospinal fluid rhinorrhea is a result of a damage to bones and dura mater of the anterior cranial fossa base. In more than 90% it is of trauamatic etiology. AIM: The aim of the study was to present a case of a 23 year old female patient with post-traumatic rhinorrhea. Cerebrospinal fluid rhinorrhea occured as a result of unintentional damage of cribriform plate of the ethmoid bone on the right side when the patient was opening a box of cosmetic with the use of a screwdriver. MATERIAL AND METHODS: Two days after the accident she was admitted to our Department with apparent cerebrospinal fluid rhinorrhea and forehead headache. Radiological and laboratory testing were performed, than she was consulted by a neurologist and a neurosurgeon. It was decided to introduce conservative management in the ENT department. RESULTS: During 24 days of hospitalization with medical management including avoidance of activities that increased the intracranial pressure, head elevation and antibiotics the cerebrospinal fluid rhinorrhea decreased and ceased. This was confirmed by physical examination, nasal endoscopy, radiological studies and neurosurgical consultation. CONCLUSIONS: After more than 3 months of follow-up, there was no evidence of rhinorrhea.