Correlates of Staff Acceptability of a Novel Telemedicine-Delivered Medications for Opioid Use Disorder Program in a Rural Detention Center.

Opioid overdose death is significantly increased immediately following incarceration. Evidence-based medications are underutilized in rural jails and detention centers. We have reported our efforts to address this gap through telemedicine-based medications for opioid use disorder treatment (tele-MOUD) for incarcerated patients. Staff acceptance and perceptions are critically important factors in the assurance of program validation. We assessed tele-MOUD acceptability and perceptions of effectiveness and stigma in one detention center. Overall, we found that jail staff's general acceptability of the program was rather low, as was perceived effectiveness of MOUD, while stigmatizing beliefs were present. Furthermore, tele-MOUD acceptability was positively correlated with perceptions of MOUD effectiveness and negatively correlated with stigmatizing notions of MOUD (p's < 0.001). Findings suggest the need for educational interventions. Future research investigating the potential moderating effects of training on staff acceptability of jail-based tele-MOUD will support the implementation and sustainability of these life-saving programs.

Firearm Ownership, Defensive Gun Usage, and Support for Gun Control: Does Knowledge Matter?

Recent incidents of gun violence have raised questions about public access to "military-style" firearms and the need for more-restrictive forms of gun control. Proponents of more-restrictive forms of gun regulation argue that such measures will help combat the disproportionately high rates of gun crime in the United States. Opponents believe that such measures infringe upon constitutional rights and hinder law-abiding citizens' abilities to adequately defend themselves. This project explores the characteristics of gun owners living in Pennsylvania and public perceptions of three different categories of gun control. Results indicate that most gun owners have received some form of training and take appropriate safety precautions with their firearms. Further, 1 in 4 gun owners reported using their firearm in self-defense at some point in their life. Regarding gun control, most participants favored strategies intended to keep guns away from dangerous and "at risk" people, such as required background checks for all types of gun purchases, mental health screenings, and mandatory gun education. However, most participants opposed complete firearm bans. Among those who are the least supportive of such polices are those who are the most knowledgeable about gun crime, gun legislation, and gun functioning. Policy implications are discussed within. Supplementary Information: The online version contains supplementary material available at 10.1007/s12103-021-09644-7.

Insights from studying prejudice in the context of American atheists.

Our research on non-religion supports the proposed shift toward more interactive models of prejudice. Being nonreligious is easily hideable and, increasingly, of low salience, leading to experiences not easily understood via traditional or contemporary frameworks for studying prejudice and prejudice reduction. This context affords new opportunity to observe reverse forms of interactive prejudice, which can interfere with prejudice reduction.

Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells.

When cells encounter substantial DNA damage, critical cell cycle events are halted while DNA repair mechanisms are activated to restore genome integrity. Genomic integrity also depends on proper assembly and function of the bipolar mitotic spindle, which is required for equal chromosome segregation. Failure to execute either of these processes leads to genomic instability, aging, and cancer. Here, we show that following DNA damage in the breast cancer cell line MCF-7, the centrosome protein centrin2 moves from the cytoplasm and accumulates in the nucleus in a xeroderma pigmentosum complementation group C protein (XPC)-dependent manner, reducing the available cytoplasmic pool of this key centriole protein and preventing centrosome amplification. MDA-MB 231 cells do not express XPC and fail to move centrin into the nucleus following DNA damage. Reintroduction of XPC expression in MDA-MB 231 cells rescues nuclear centrin2 sequestration and reestablishes control against centrosome amplification, regardless of mutant p53 status. Importantly, the capacity to repair DNA damage was also dependent on the availability of centrin2 in the nucleus. These observations show that centrin and XPC cooperate in a reciprocal mechanism to coordinate centrosome homeostasis and DNA repair and suggest that this process may provide a tractable target to develop treatments to slow progression of cancer and aging.

The effect of school on overweight in childhood: gain in body mass index during the school year and during summer vacation.

OBJECTIVES: To determine whether school or nonschool environments contribute more to childhood overweight, we compared children's gains in body mass index (BMI) when school is in session (during the kindergarten and first-grade school years) with their gains in BMI when school is out (during summer vacation). METHODS: The BMIs of 5380 children in 310 schools were measured as part of the Early Childhood Longitudinal Study, Kindergarten Cohort. We used these measurements to estimate BMI gain rates during kindergarten, summer, and first grade. RESULTS: Growth in BMI was typically faster and more variable during summer vacation than during the kindergarten and first-grade school years. The difference between school and summer gain rates was especially large for 3 at-risk subgroups: Black children, Hispanic children, and children who were already overweight at the beginning of kindergarten. CONCLUSIONS: Although a school's diet and exercise policies may be less than ideal, it appears that early school environments contribute less to overweight than do nonschool environments.