ABSTRACT
PURPOSE: Our main objective is to evaluate the psychometric properties of the Spanish version of the EHP-30 questionnaire. The secondary aim is to evaluate the differences in the scores of the core EHP-30 scales between patients with either surgical treatment or conservative management of endometriosis. METHODS: Cross-sectional study conducted into a tertiary hospital endometriosis reference unit. All patients (n = 223) pre-surgically completed the core EHP-30 questionnaire, the EQ-5D questionnaire (n = 184) and a visual analogue scale (n = 210) for endometriosis-related pain. Demographical and clinical data were recorded. RESULTS: Psychometric characteristics of the Spanish core EHP-30 questionnaire were investigated. Statistical analyses confirmed the five-structure factor, a high degree of internal consistency and of item-total correlation for all the assessed items. Convergent validity between EQ-5D and EHP-30 items and between VAS and EHP-30 subscale pain was observed. Additionally, patients with surgical management rendered significantly higher scores in the core EHP-30 subscales "pain" and "control and powerlessness". CONCLUSIONS: We present the reliability, validity and acceptability of the Spanish core EHP-30 questionnaire, providing clinicians and researchers with an improved tool to assess the endometriosis-related quality of life. Additionally, we show that patients subsidiaries of surgical treatment for endometriosis present with higher pain and powerlessness than those with conservative management.
Subject(s)
Endometriosis , Quality of Life , Cross-Sectional Studies , Endometriosis/complications , Endometriosis/diagnosis , Endometriosis/surgery , Female , Humans , Psychometrics , Reproducibility of Results , Surveys and QuestionnairesABSTRACT
La implantación de embriones en el útero materno implica un diálogo embrión-endometrio en el que participan gran cantidad de moléculas. El objetivo de este estudio fue detectar en el medio de cultivo embrionario moléculas implicadas en este proceso tanto de embriones provenientes de ciclos estimulados con gonadotropina recombinante como con humana ultrapurificada (Fostipur®). Para ello se analizó el edio donde se habían cultivado los embriones hasta su transferencia en día dos de desarrollo. El tipo de gonadotropina utilizada no pareció afectar a la secreción de moléculas, excepto en el caso de HBEGF.Tampoco se encontraron diferencias significativas entre los embriones que implantaban y los que no. Aún así, sí se observó una secreción diferencial entre los dos grupos, por lo que serán necesarios más estudios para poder utilizar con fiabilidad estas moléculas como marcadores de viabilidad embrionaria (AU)
Embryo implantation involves a complex dialogue between the embryo and endometrium in which large number of molecules take part. The aim of this study was to identify molecules involve in this process, in culture medium of embryo coming from stimulated cycles by both recombinant and ultra-purified gonadotropin (Fostipur®). For this purpose we analyzed the medium where embryos had been cultivated until the embryo transfer in day two of development. The kind of used gonadotropin seems not to affect molecules secretion except HB-EGF. There were not found any significant differences between implanted and not implanted embryos. Even so, it was noticed a differential secretion between both two groups. Consequently, more studies will be necessary to use these molecules as embryo viability biomarkers (AU)
