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2.
Asian Cardiovasc Thorac Ann ; 25(9): 635-637, 2017 Nov.
Article in English | MEDLINE | ID: mdl-29022827

ABSTRACT

We report open surgical repair of a previously stented descending thoracic aneurysm in a patient with Wiskott-Aldrich syndrome and a platelet count <10 × 109·L-1. The same patient was described previously in a report of the first endovascular stent in this form of vasculitis. We describe the pre- and intraoperative management, and suggest a change in strategy in this setting.


Subject(s)
Aortic Aneurysm, Thoracic/surgery , Blood Platelets , Blood Vessel Prosthesis Implantation/methods , Platelet Transfusion , Wiskott-Aldrich Syndrome/complications , Adult , Aortic Aneurysm, Thoracic/blood , Aortic Aneurysm, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/etiology , Aortography/methods , Blood Platelets/immunology , Blood Vessel Prosthesis Implantation/adverse effects , Computed Tomography Angiography , Humans , Immunoglobulins, Intravenous/administration & dosage , Magnetic Resonance Imaging , Male , Platelet Count , Treatment Outcome , Wiskott-Aldrich Syndrome/blood , Wiskott-Aldrich Syndrome/diagnosis , Wiskott-Aldrich Syndrome/immunology
3.
J Heart Lung Transplant ; 35(3): 312-319, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26612054

ABSTRACT

BACKGROUND: In this study we investigated the development of aortic incompetence (AI) and change in aortic root and left ventricular dimensions after implantation of the continuous-flow HeartWare ventricular assist device (HVAD) in our adult patient cohort. METHODS: A retrospective analysis of serial echocardiograms was performed on patients implanted with an HVAD between July 2009 and July 2013. Data from echocardiograms performed before and at 1 and 2 years (±3 months) were analyzed. Patients with native aortic valves (AoVs) with no previous intervention and HVAD in situ for ≥6 months were included. RESULTS: A total of 73 HVADs in 71 patients with a mean duration of support of 624 ± 359 days were included in our study. One patient developed moderate AI at 1 year (1.9%). Mild or greater AI was more likely in those with a closed or intermittently opening AoV at 1 year (p = 0.005). Aortic annulus dimensions increased significantly at 1 and 2 years, regardless of extent of AI. At 2 years, in those with mild or worse AI, the sinuses of Valsalva were also larger (p = 0.002). Left ventricular end-diastolic dimension (LVEDD) was significantly reduced in those with no or trace AI at 1 and 2 years (p = 0.012 and p = 0.008, respectively), but remained unchanged in those with AI at both time-points. CONCLUSIONS: The development of more than mild AI is rare in HVAD patients at our center. When encountered, it is more common with a closed AoV. Dilation of the aortic annulus, and root dilation in those with mild or more AI, is seen with HVAD support over time.


Subject(s)
Aortic Valve Insufficiency/etiology , Heart-Assist Devices/adverse effects , Aortic Valve Insufficiency/diagnostic imaging , Echocardiography , Female , Humans , Male , Middle Aged , Prosthesis Design , Retrospective Studies
4.
Ann Card Anaesth ; 18(4): 599-602, 2015.
Article in English | MEDLINE | ID: mdl-26440254

ABSTRACT

The indication of pacemaker/AICD removal are numerous. Serious complication can occur during their removal, severe tricuspid regurgitation is one of the complication. The occurrence of PFO is not uncommon among adult population. Shunting across PFO in most circumstance is negligible, but in some necessitates closure due to hypoxemia. We report a case of 62 year old man, while undergoing AICD removal, had an emergency sternotomy for cardiac tamponade. Postoperatively, he experienced profound hypoxemia refractory to oxygen therapy. Transthoracic Echocardiogram was performed to rule out intracardiac shunts at an early stage, but it was difficult to obtain an good imaging windows poststernotomy. A small pulmonary emboli was noted on CTPA, but was not sufficient to account for the level of hypoxemia and did not resolve with anticoagulation. Transesophageal echocardiogram showed flail septal tricuspid valve with severe TR and bidirectional shunt through large PFO. Patient was posted for surgery, tricuspid valve was replaced and PFO surgically closed. Subsequently, patient recovered well ad was discharged to home. Cause of hypoxemia might be due to respiratory or cardiac dysfunction. But for hypoxemia refractory to oxygen therapy, transoesophageal echocardiogram should be always considered and performed early as an diagnostic tool in post cardiac surgical patients.


Subject(s)
Defibrillators, Implantable , Device Removal , Hypoxia/etiology , Postoperative Complications/diagnostic imaging , Tricuspid Valve Insufficiency/complications , Echocardiography, Transesophageal , Humans , Hypoxia/surgery , Male , Middle Aged , Postoperative Complications/surgery , Tricuspid Valve/diagnostic imaging , Tricuspid Valve/surgery , Tricuspid Valve Insufficiency/diagnostic imaging , Tricuspid Valve Insufficiency/surgery
5.
Ann Thorac Surg ; 98(6): 2122-9, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25443016

ABSTRACT

BACKGROUND: The systemic morphologic right ventricle (RV) in congenitally corrected transposition of the great arteries or after atrial switch for transposition of the great arteries is associated with late ventricular failure. Although the role of the left ventricular assist device (LVAD) in supporting the failing LV is established, the indications and outcomes of using LVAD in a systemic RV remain unclear. We assessed the role of a third-generation LVAD for systemic RV support. METHODS: Seven patients (mean age, 36 years) received the HeartWare (HeartWare International Inc, Framingham, MA) VAD for systemic RV failure (congenitally corrected transposition of the great arteries in 1 and after atrial switch in 6). Four patients (57%) had severe subpulmonic LV failure, and aggressive perioperative diuresis with or without hemofiltration was used to offload the subpulmonic LV. The indications of VAD were (1) bridge to transplant in 3 and (2) bridge to decision for a high transpulmonary gradient in 4. Transplantation outcome was compared with systemic RV failure without VAD bridge in 19 patients (years 1989 to 2013). RESULTS: Systemic RV support alone was achieved in all patients, with no early deaths (≤30 days). Overall, 6 (86%) returned home, 3 (44%) received a transplant, 2 (28%) died of noncardiac causes, and 2 (28%) continue on VAD support (median support, 232 days). Repeat catheterization (n = 4) showed an improved median transpulmonary gradient in 3 patients (median 18.5 mm Hg pre-VAD vs 8.0 mm Hg post-VAD). Two bridge-to-decision patients received transplants at 640 and 685 days. The stroke rate on VAD support was 43% (2 thromboembolic and 1 hemorrhagic; 3 with satisfactory recovery). De novo aortic regurgitation was 29% (n = 2; 1 valve replacement). All patients (n = 3) survived transplantation (vs 10.5% early mortality without VAD bridge; p = 1.00) and were well at follow-up (range, 53 to 700 days). CONCLUSIONS: The third-generation VAD provides durable support for systemic RV failure as a bridge to transplant and as a strategy to reduce pulmonary vascular resistance. Although concomitant subpulmonic LV failure is common, systemic RV support alone was achieved in all patients.


Subject(s)
Durable Medical Equipment , Heart Failure/prevention & control , Heart-Assist Devices , Transposition of Great Vessels/complications , Ventricular Dysfunction, Right/surgery , Ventricular Function, Right/physiology , Adult , Echocardiography , Equipment Design , Female , Follow-Up Studies , Heart Failure/etiology , Heart Failure/physiopathology , Heart Ventricles/diagnostic imaging , Heart Ventricles/physiopathology , Humans , Male , Retrospective Studies , Time Factors , Treatment Outcome , Vascular Resistance , Ventricular Dysfunction, Right/complications , Ventricular Dysfunction, Right/physiopathology
6.
Ann Card Anaesth ; 16(4): 259-67, 2013.
Article in English | MEDLINE | ID: mdl-24107692

ABSTRACT

Left ventricular assist devices (LVAD) are increasingly used for mechanical circulatory support of patients with severe heart failure, primarily as a bridge to heart transplantation. Transesophageal echocardiography (TEE) plays a major role in the clinical decision making during insertion of the devices and in the post-operative management of these patients. The detection of structural and device-related mechanical abnormalities is critical for optimal functioning of assist device. In this review article, we describe the usefulness of TEE for optimal perioperative management of patients presenting for HeartWare LVAD insertion.


Subject(s)
Echocardiography, Transesophageal , Heart-Assist Devices , Aortic Valve Insufficiency/physiopathology , Catheters , Foramen Ovale, Patent/physiopathology , Humans , Tricuspid Valve Insufficiency/physiopathology , Ventricular Function, Right
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