Subject(s)
Calcium Channel Blockers/administration & dosage , Myocardial Ischemia/drug therapy , Verapamil/administration & dosage , Aged , Angina Pectoris/drug therapy , Angina Pectoris/physiopathology , Chronic Disease , Drug Evaluation , Hemodynamics/drug effects , Humans , Methods , Middle Aged , Myocardial Ischemia/physiopathology , Physical ExertionABSTRACT
The study was undertaken to examine central hemodynamic and carbohydrate metabolic parameters in patients with coronary heart disease (with or without signs of chronic heart failure, Stages I and IIA). The changes in carbohydrate metabolism in CHD patients were detected earlier than those in central hemodynamics. In patients with Stage I heart failure, who had normal resting hemodynamic parameters, metabolic parameters were indicative of abnormalities in carbohydrate metabolism: there was a reduction in carbohydrate tolerance and red blood cell release of insulin in response to glucose load and an increase in blood immunoreactive insulin, erythrocytic glucose-6-phosphate dehydrogenase activity and greater adrenalin- and insulin-containing erythrocytes. It is suggested that it is advisable to determine the above parameters of carbohydrate metabolism in patients with coronary heart disease.
Subject(s)
Carbohydrates/blood , Cardiac Output, Low/physiopathology , Coronary Disease/physiopathology , Hemodynamics , Cardiac Output, Low/blood , Cardiac Output, Low/complications , Coronary Disease/blood , Coronary Disease/complications , Female , Humans , Male , Middle AgedABSTRACT
A study is presented of the central hemodynamics, renal function and water-salt metabolism in 42 patients with ischemic heart disease and chronic circulatory insufficiency (grades I and II) and revealed a deterioration of these indices in this categories of patients manifested in a retention of sodium, deterioration of central hemodynamics after increase of venous inflow.
