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Colorectal Dis ; 12(11): 1153-8, 2010 Nov.
Article in English | MEDLINE | ID: mdl-19863608

ABSTRACT

AIM: Colorectal cancer is common, accounting for nearly 10% of all cancers. Transforming growth factor-ß1 (TGF-ß1) is a pleiotropic cytokine that has been implicated in the pathogenesis of colorectal neoplasia. The most studied -509C>T polymorphism of TGF-ß1 gene has been associated with various kinds of cancer. This study investigated the association between this genetic variant and the risk and/or progression of colorectal cancer. METHOD: A case-control study was carried out of 150 colorectal cancer cases and 503 healthy controls. DNA was extracted from blood cell nuclear materials, and -509C>T polymorphism in the TGF-ß1 gene promoter was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Colorectal cancer tissues (n = 70) were obtained from the studied cases for measurement of TGF-ß1 mRNA expression levels. We also assessed the plasma TGF-ß1 levels of cases (n = 88) and healthy subjects (n = 120). RESULTS: The TGF-ß1 producer genotype, -509TT, was not associated with an increased risk of colorectal cancer compared with other genotypes. Colorectal cancer patients especially those with a more aggressive disease behaviour were more frequently associated with C allele. CONCLUSION: The results suggest that TGF-ß1 -509C>T polymorphism is not associated with either an increased risk or progression of colorectal cancer.


Subject(s)
Chromosomes, Human, 19-20/genetics , Colorectal Neoplasms/genetics , Polymorphism, Single Nucleotide/genetics , Promoter Regions, Genetic/genetics , Transforming Growth Factor beta1/genetics , Asian People , Case-Control Studies , China/epidemiology , Colorectal Neoplasms/epidemiology , Disease Progression , Female , Genetic Predisposition to Disease , Genotype , Humans , Male , Middle Aged
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