Detection of In Vivo-like Cells by a Biosensor Chip Based on Metamaterials in Terahertz Regime.

Early diagnosis of diseases, especially cancer, is critical for effective treatment. The unique properties of terahertz technology have attracted attention in this field. However, current terahertz bio-detection methods face challenges due to differences between the test environment and the actual in vivo conditions. In this study, a novel method is proposed for detecting in vivo-like cells using a biosensor chip composed of metamaterials and a cavity. The cavity has a thickness of ~50 µm. The structure can protect cells from damage and provides a liquid environment like an in vivo state. Through simulation analysis, the metamaterials sensor exhibits a theoretical sensitivity of 0.287 THz/RIU (Refractive Index Unit) with a 50 µm thick analyte. The detection method is experimentally validated using the apoptosis of glioma cells and various cell types. The biosensor investigates the apoptosis of glioma cells under the impact of temozolomide, and the trend of the results was consistent with the Cell Counting Kit-8 method. Furthermore, at a concentration of ~5200 cells/cm2, the experimental results demonstrate that the sensor can distinguish between neurons and glioma cells with a resonance frequency difference of approximately 30 GHz. This research has significant potential for detecting glioma cells and offers an alternative approach to in vivo-like cell detection.

Investigating the Molecular Rearrangement of Polar Liquid Mixtures Using Terahertz Frequency Domain Reflection Spectroscopy.

A special data processing method for the terahertz frequency domain reflection spectroscopy system has been proposed to analyze the characteristics of a polar mixed liquid. This novel and practical measurement system is characterized by a simpler optical structure and a tunable output frequency range of 0.1-1 THz. By Hilbert transform, stationary wavelet transform, and time domain zero setting method, the reflection coefficient that has been eliminated by the noise and the Fabry-Pérot effect can be obtained by the self-reference calibration method. Then, the dielectric function of the ethanol/n-hexane and propanol/n-hexane mixtures with different mixture ratios can be extracted by this method. In addition, a significant deviation can be observed between the imaginary part of the measured dielectric function and the ideal calculated value. These results indicate that during the mixing process of polar and nonpolar liquids, the hydroxyl functional groups of alcohols significantly change the molecular arrangement pattern of the mixture. The arrangement pattern will result in the formation of the new permanent dipole moment. This study lays a solid foundation for future research on the microscopic mechanism of intermolecular interaction using terahertz frequency domain reflection spectroscopy.

Ultra-sensitive terahertz metamaterials biosensor based on luxuriant gaps structure.

Fast, simple, and label-free detections and distinctions are desirable in cell biology analysis and diagnosis. Here, a biosensor based on terahertz metamaterial has luxuriant gaps, which can excite dipole resonance is designed. Filling the gaps with various analytes can change the biosensor's capacitance resulting in electromagnetic properties changing. The idea is verified by simulations and experiments. The theoretical sensitivity of the biosensor approaches 290 GHz/RIU, and the experimental concentration sensitivity of the biosensor is ≥ 275 kHz mL/cell. Candida Albicans, Escherichia Coli, and Shigella Dysenteriae were selected as analytes, and the measurement frequency shift is 270 GHz, 290 GHz, and 310 GHz, respectively, which indicates that the biosensor can detect and distinguish these bacteria. Successfully detection of low-concentration glioblastoma (200 cells/mL), showing great potential for the early diagnosis of glioblastoma of the biosensor. This biosensor supplies a new horizon for cell detection, which will significantly benefit cell biology investigation.

Simple Design of Broadband Polarizers Using Transmissive Metasurfaces for Dual Band Ku/Ka Band Applications.

Major challenges affecting polarizers for communication systems include the inability to perform over a wide bandwidth with a simple design. Orthogonal outgoing polarization for polarization-diverse applications and stable performances for oblique incidence angles are also major requirements. This paper presents the design of a polarizer that can perform over a wide range of bandwidths in dual frequency bands. The unit cell is uniquely designed using a split circular ring resonator enclosed in a square ring with the addition of three-square patches. As a result, the incoming linearly polarized x(y) wave is converted into a transmitted LHCP (RHCP) wave in the Ku and Ka bands. The operational bandwidths are 11.05~16.75 GHz (41%) and 34.16~43.03 GHz (23%). The proposed polarizer is ultrathin, works in dual wide-bands, is polarization-diverse, and maintains performance over ±45° and ±30° oblique incidences, which makes it a strong candidate for many communication systems.

Double-mode and double-beam staggered double-vane traveling-wave tube with high-power and broadband at terahertz band.

In this paper, a 220 GHz broadband and high-power staggered double-vane traveling-wave tube has been designed and verified. Firstly, a planar double-beam staggered double-vane slow-wave structure is proposed. By using the double-mode operation scheme, the transmission performance and bandwidth have been almost increased with twice as the single mode. Second, to satisfy the high output power requirement and improve the stability of the traveling-wave tube, a double pencil-beam electron optical system has been designed, the 20-21 kV driven voltage and the 2 × 80 mA current are set as the design target. By using the mask portion and the control electrode in the double beam gun, the two pencil beams can be focused with a compression ratio of 7 along their respective centers with narrow distances of about 0.18 mm with good stability. The uniform magnetic focusing system has also been optimized. The stable transmission distance of planar double electron beams could reach 45 mm with the focusing magnetic field of 0.6 T, which was long enough to cover the whole high-frequency system (HFS). Then, to verify the availability of the electron optical system and the performance of the slow-wave structure, particle-in-cell (PIC) simulation has also been carried out with the whole HFS. Results demonstrate that the beam-wave interaction system can get a nearly 310 W peak output power at 220 GHz with a 20.6 kV optimized beam voltage and beam current of 2 × 80 mA, the gain is of 38 dB with the 3-dB bandwidth over 35 dB about 70 GHz. Finally, the high precision microstructures fabrication has been carried out to verify the performance of the HFS, the results show that the bandwidth and the transmission properties are in good agreement with simulation result. Thus, the proposed scheme in this paper is expected to develop the high-power and ultra-wideband terahertz band radiation source with potential applications in the future.

Transmissive Polarizer Metasurfaces: From Microwave to Optical Regimes.

Metasurfaces, a special class of metamaterials, have recently become a rapidly growing field, particularly for thin polarization converters. They can be fabricated using a simple fabrication process due to their smaller planar profile, both in the microwave and optical regimes. In this paper, the recent progress in MSs for linear polarization (LP) to circular polarization (CP) conversion in transmission mode is reviewed. Starting from history, modeling and the theory of MSs, uncontrollable single and multiple bands and LP-to-CP conversions, are discussed and analyzed. Moreover, detailed reconfigurable MS-based LP-to-CP converters are presented. Further, key findings on the state-of-the-arts are discussed and tabulated to give readers a quick overview. Finally, a conclusion is drawn by providing opinions on future developments in this growing research field.

Research on a high-sensitivity asymmetric metamaterial structure and its application as microwave sensor.

In this paper, an Asymmetric Electric Split-Ring Resonator (AESRR) metamaterial structure is proposed to explore the interaction between metamaterials and electromagnetic waves with the influence of Fano resonance on electromagnetic properties. With the symmetry of basic electric Split-Ring Resonator (eSRR) being broken, a new Fano resonant peak appears at around 11.575 GHz and this peak is very sensitive to the dielectric environment. Based on the proposed high sensitivity of AESRR, a microwave sensor based on a 13 × 13 arrays of AESRR was designed and verified using printed circuit board (PCB) technology. T-shape channel was integrated to the sensor by grooving in the FR-4 substrate which improved the integration and provided the feasibility of liquids detection. Seven organic liquids and four dielectric substrates are measured by this sensor. The measured results show the transmission frequency shifts from 11.575 to 11.150 GHz as the liquid samples permittivity changes from 1 to 7 and the transmission frequency shifts from 11.575 to 8.260 GHz as the solid substrates permittivity changes from 1 to 9. The results have proven the improved sensitivity and the larger frequency shift ∆f on material under test (MUTs) compared with the conventional reported sensor. The relative permittivity of liquid samples and solid samples can be obtained by establishing approximate models in CST, respectively. Two transcendental equations derived from measured results are proposed to predict the relative permittivity of liquid samples and solids samples. The accuracy and reliability of measured results and predicted results are numerically verified by comparing them with literature values. Thus, the proposed sensor has many advantages, such as low-cost, high-sensitivity, high-robustness, and extensive detecting range, which provided a great potential to be implemented in a lab-on-a-chip sensor system in the future.

Horizontal Polarized DC Grounded Omnidirectional Antenna for UAV Ground Control Station.

A new slot-based antenna design capable of producing horizontal polarization for unmanned aerial vehicle (UAV) ground control station (GCS) applications is outlined in this paper. The proposed antenna consists of oversize coaxial cylinders, slots, and slot-feed assembly. Each of the four vertical slots, arranged periodically around the antenna's outer cylinder, emits a horizontally polarized broad beam of radiation, in phase, to produce an omnidirectional pattern. The antenna possesses a low-ripple ±0.5 dB in azimuth gain (yaw) due to its symmetric axis shape and an enclosed feed within itself, which does not radiate and interfere with the main azimuth pattern. This is crucial for a UAV GCS to symmetrically extend its coverage range in all directions against yaw planes. Simulation and measurement results reveal that the antenna maintains stable gain in the omnidirectional pattern (+0.5 dB) over the entire operational frequency band (2.55 GHz to 2.80 GHz), where S11 is lower than -10 dB. A further advantage of this configuration is its enhanced polarization purity of -40 dB over the full frequency band. The direct-current (DC) grounding approach used in this antenna is beneficial due to its electrostatic discharge (ESD) and lightning protection. Furthermore, its aerodynamic, self-supporting, and surface-mount structural shape makes this antenna a good and worthy choice for a UAV GCS.

High-power vacuum terahertz photomixer and integrated circuits based on microscale phototubes.

Technologies and industrials in long-distance communication, detection, and imaging applications are still in great need of higher-output-power terahertz sources. This paper proposes two kinds of microscale vacuum phototube based high-power terahertz source: vacuum photomixer and terahertz integrated circuit. The principle of photomixer based on photoemission and field-assisted photoemission is demonstrated. Its capability of producing radiation power beyond 1 mW is estimated based on theoretical analysis and experimental evidence. Simulation and theoretical analysis have shown that the fundamental THz photodiode devices can operate with a space-charge limited current density of 4496 A/cm2 at 60 V, and the amplifier circuits are calculated to have a gain performance of around 10 dB. The two photoemission-based roadmaps have the potential to be developed from an emerging and interdisciplinary field to more promising future directions of THz science and technology.

Design of planar distributed three beam electron gun with narrow beam separation for W band staggered double vane TWT.

A novel planar distributed three-beam electron gun with narrow beam separations is designed based on grids loaded sheet beam method. The dimensions of the three-beam gun in the y-O-z plane are determined using our basic theoretical design method developed for sheet beam gun. The results show that the profile of focusing electrode in the y-O-z plane is related to the beam width in the x-O-z plane. Then, the characteristics and parameters of three-beam array formation with their stability are analyzed thoroughly by adjustment of control grids in the x-O-z plane. Each of the beamlet obtained is with a small axial deviation of the two transverse waists. Based on the theoretical analysis and simulations, the planar three-beam electron gun is constructed with the beam voltage of 22 kV and the current of 3 [Formula: see text] 0.15 A. The average radius of 0.08 mm at each beam waist is obtained with the compression factor of 4 for the 0.18 mm beam tunnel radius. The beam waist can be achieved at about 4.4 mm away from the cathode with the axis separation about 0.46 mm for each of beamlet. Thus, the design method can be generally used to construct such type of narrow beam separation and planar distributed multiple beam electron gun for the miniaturization and integrated vacuum electron devices in millimeter wave and terahertz band.

Multiple-beam and double-mode staggered double vane travelling wave tube with ultra-wide band.

This paper presents design, fabrication and cold test of an ultra-wide band travelling wave tube (TWT) with planar alignment multiple pencil beams. The fundamental double-mode of staggered double vane slow wave structure (SDV-SWS) rather than the only one mode are put forward and adopted to match with the same electron beam to increase the bandwidth greatly. Simultaneous planar alignment multiple pencil beam tunnels are designed to improve interaction impedance and then to enhance output power, gain, efficiency, growth rate. The transmission performance of a two-stage 51-period SDV-TWT in G-band with structure attenuator between two sections shows that it indeed has an ultra-wideband performance from 81 to 110 GHz. By using computer numerical control machining, the SDV-SWS was manufactured and a detailed cold test was conducted. Good agreement is found at the wide band, where S21 is above - 5 dB and S11 is below - 10 dB. 3D PIC simulations with double-mode multiple-beam SDV-TWT within total length of 70 mm show that it can get a nearly 2120 W peak output power, a 42.5 dB corresponding gain and a 10.7% electron efficiency at 94 GHz with a 22.1 kV beam voltage and a 3 × 0.15A beam current. The 3 dB bandwidth of our double-mode SDV-TWT can achieve about 29 GHz.

Triple-wide-band Ultra-thin Metasheet for transmission polarization conversion.

Polarization converters play an important role in modern communication systems, but their wide and multiple band operation to facilitate volume and size reduction is quite challenging. In this paper, a triple-band Linear Polarization to Circular Polarization (LP-to-CP) converter is presented using a novel design procedure based on geometric parameters optimization of a metasheet. The proposed converter is ultrathin, wideband, stable over a wide range of incident angles, and polarization diverse. The conductor layer of metasheet is patterned with a square ring and five square-patches diagonally intersecting each other. To validate the proposed method, an LP-to-CP convertor in X-band (7.3~9.6 GHz) and dual Ka-bands (25.4~31.4 GHz, 35.4~42.2 GHz) is presented. The performance is quite stable in wide range of frequencies and against the variation of incident angles from -25° to 25°. After performing model-based theoretical paradigm analysis, and full-wave simulation and optimization, the converter is fabricated and the measurements are performed inside the anechoic chamber. The measured results, close to simulation results, depict the validity and reliability of the proposed design.

Super Wide Band, Defected Ground Structure (DGS), and Stepped Meander Line Antenna for WLAN/ISM/WiMAX/UWB and other Wireless Communication Applications.

This paper presents a new shape (s-shape monopole) of a super wideband antenna using stepped meander lines, a quarter waveguide transformer feeding line, and a defected ground structure (DGS). The antenna will be used for multiple wireless communication applications like WIMAX/WLAN/ISM/UWB, and also for several wireless communication applications. The total dimensions of the proposed antenna are 35 mm × 35 mm × 1.57 mm or 0.36 λo × 0.36 λo × 0.016 λo, which are the corresponding electrical dimensions with free-space wavelength (λo) at the lower operating frequency. The antenna is designed and simulated into two steps: the first (Antenna 1) covers a bandwidth of 18.2 GHz, while the second (Antenna 2, using DGS) covers a super wide bandwidth of 37.82 GHz (3.08-40.9 GHz). The measured fractional bandwidth and bandwidth ratio of the antenna are 174.68% and 13.009:1, respectively, which is operating from 3.09-40.2 GHz. The maximum calculated gain and efficiency are 5.9 dBi and 92.7%, respectively. The time-domain performance is good due to the calculation of the system fidelity factor, group delay, and its linear and constant phase variation.

Extremely Sensitive Microwave Sensor for Evaluation of Dielectric Characteristics of Low-Permittivity Materials.

In this paper, an extremely sensitive microwave sensor is designed based on a complementary symmetric S shaped resonator (CSSSR) to evaluate dielectric characteristics of low-permittivity material. CSSSR is an artificial structure with strong and enhanced electromagnetic fields, which provides high sensitivity and a new degree of freedom in sensing. Electromagnetic simulation elucidates the effect of real relative permittivity, real relative permeability, dielectric and magnetic loss tangents of the material under test (MUT) on the resonance frequency and notch depth of the sensor. Experiments are performed at room temperature using low-permittivity materials to verify the concept. The proposed design provides differential sensitivity between 102% to 95% as the relative permittivity of MUT varies from 2.1 to 3. The percentage error between simulated and measured results is less than 0.5%. The transcendental equation has been established by measuring the change in the resonance frequency of the fabricated sensor due to interaction with the MUT.

High Efficient and Ultra Wide Band Monopole Antenna for Microwave Imaging and Communication Applications.

The paper presents a highly efficient, low cost, ultra-wideband, microstrip monopole antenna for microwave imaging and wireless communications applications. A new structure (z-shape, ultra-wideband (UWB) monopole) is designed, which consists of stepped meander lines to achieve super-wide bandwidth and high efficiency. Three steps are used to design the proposed structure for the purpose to achieve high efficiency and wide bandwidth. The antenna bandwidth is enhanced by varying the length of meander line slots, optimization of the feeding line and with the miniaturization of the ground width. The simulated and measured frequency bands are 2.7-22.5 GHz and 2.8-22.7 GHz (156% fractional bandwidth), respectively. The dimensions of the antenna are 38 mm × 35 mm × 1.57 mm, and its corresponding electrical size is 2.41 λg × 2.22 λg × 0.09 λg, where guided wavelength λg is at the center frequency (12.75 GHz). This antenna achieved a high bandwidth ratio (8.33:1). The realized gain is varying from 1.6-6.4 dBi, while that of efficiency is 70% to 93% for the whole band. Radiation patterns are measured at four operating frequencies. It has an acceptable group delay, fidelity factor, and phase variation results that satisfy the limit of ultra-wideband in the form of the time domain.

Complementary Metamaterial Sensor for Nondestructive Evaluation of Dielectric Substrates.

In this paper, complementary metamaterial sensor is designed for nondestructive evaluation of dielectric substrates. The design concept is based on electromagnetic stored energy in the complementary circular spiral resonator (CCSR), which is concentrated in small volume near the host substrate at resonance. This energy can be employed to detect various electromagnetic properties of materials under test (MUT). Effective electric permittivity and magnetic permeability of the proposed sensor is extracted from scattering parameters. Sensitivity analysis is performed by varying the permittivity of MUT. After sensitivity analysis, a sensor is fabricated using standard PCB fabrication technique, and resonance frequency of the sensor due to interaction with different MUT is measured using vector network analyzer (AV3672series). The transcendental equation is derived for the fabricated sensor to calculate relative permittivity for unknown MUTs. This method is very simple and requires calculating only the resonant frequency, which reduces the cost and computation time.

Broadband and high-power terahertz radiation source based on extended interaction klystron.

Terahertz applications require high performance and high reliability terahertz radiation sources, especially the urgent demands of high output power and broad bandwidth. The extended interaction klystron (EIK) has the great potential to generate hundreds of watt output power in terahertz band. The terahertz EIK adopts multiple gap cavities and unequal-width slots structure is proposed with methodological improvement of bandwidth and output power. The unequal-width slots are the key design of the multiple gap cavity, and the influences of unequal-width slots on the electromagnetic field distribution and beam-wave interaction are analyzed in detail. With multiple gap cavities and unequal-width slots structure, EIK has advantages of wider frequency separation and larger effective characteristic impedance. Particle in cell (PIC) simulation indicates that the bandwidth of unequal-width slots structure can reach to 550 MHz in our initial G-band EIK design. Then, we utilize two kinds of resonance cavities with different width ratios to build a six-cavity beam-wave interaction system and make it operate at the state of stagger-tuning, the bandwidth can be extended to 1-1.5 GHz. Our research shows that the unequal-width slots structure has wider tuning frequency range. Furthermore, the bandwidth can be further broadened to over 2 GHz when dynamic-tuning is adopted, while maintains a high output power of 560 W with efficiency of 11.3% and gain of 47.5 dB. Thus, the methods of multiple gap cavities with unequal-width slots structure, stagger-tuning and dynamic-tuning are much important for the bandwidth improvement of EIK in terahertz band.

High-Sensitivity Microwave Sensor for Liquid Characterization Using a Complementary Circular Spiral Resonator.

This paper describes a low-cost, small size, and high-sensitivity microwave sensor using a Complementary Circular Spiral Resonator (CCSR), which operates at around 2.4 GHz, for identifying liquid samples and determining their dielectric constants. The proposed sensor was fabricated and tested to effectively identify different liquids commonly used in daily life and determine the concentrations of various ethanol⁻water mixtures at by measuring the resonant frequency of the CCSR. Using acrylic paint, a square channel was drawn at the most sensitive position of the microwave sensor to ensure accuracy of the experiment. To estimate the dielectric constants of the liquids under test, an approximate model was established using a High-Frequency Simulator Structure (HFSS). The results obtained agree very well with the existing data. Two parabolic equations were calculated and fitted to identify unknown liquids and determine the concentrations of ethanol⁻water mixtures. Thus, our microwave sensor provides a method with high sensitivity and low consumption of material for liquid monitoring and determination, which proves the feasibility and broad prospect of this low-cost system in industrial application.

High resolution continuous wave terahertz spectroscopy on solid-state samples with coherent detection.

We systematically investigate the data analysis methods in terahertz frequency domain spectroscopy (THz-FDS) with coherent detection. We demonstrate that the Hilbert transform method is one of the most appropriate for data processing in THz-FDS. By converting frequency-domain signal into time domain with further data processing, the system noise due to Fabry-Pérot (FP) interference is greatly restrained. Accurate permittivity of lactose monohydrate is successfully extracted under the condition of the existence of atmospheric water vapor. Our work greatly promotes the development of THz spectroscopy in practical applications.

Highly efficient generation of 0.2 mJ terahertz pulses in lithium niobate at room temperature with sub-50 fs chirped Ti:sapphire laser pulses.

We demonstrate generation of 0.2 mJ terahertz (THz) pulses in lithium niobate driven by Ti:sapphire laser pulses at room temperature. Employing tilted pulse front technique, the 800 nm-to-THz energy conversion efficiency has been optimized to 0.3% through chirping the sub-50 fs pump laser pulses to overcome multi-photon absorption and to extend effective interaction length for phase matching. Our approach paves the way for mJ-level THz generation via optical rectification using existing Ti:sapphire laser systems which can deliver Joule-level pulse energy with sub-50 fs pulse duration.