Antibiotic-free ocular sterilization while suppressing immune response to protect corneal transparency in infectious keratitis treatment.

Clinical guidelines for infectious keratitis treatment require that anti-inflammatory drugs can only be used after infection elimination, which causes irreversible inflammatory damage to the cornea. In this work, photodynamic metal organic frameworks (PCN-224) were used as drug carrier to load Pt NPs with catalase-like activity and anti-inflammatory drug (Dexamethasone, DXMS) for endogenous oxygen generation and reduced corneal damage, respectively. The photodynamic therapy (PDT) effect was greatly enhanced in bacteria elimination and bacterial biofilms removal through catalysis of overexpressed hydrogen peroxide (H2O2, ∼8.0 and 31.0 µM in bacterial solution and biofilms, respectively) into oxygen by Pt NPs. More importantly, the cationic liposome modified PCN-224@Pt@DXMS@Liposomes (PPDL NPs) greatly enhanced the adhesion to negatively charged ocular surface and penetration into corneal barrier and bacterial biofilms. Both in vitro cell viability test and in vivo eye irritation tests proved good biocompatibility of PPDL NPs under 660 nm laser irradiation. Furthermore, PDT of PPDL NPs in rapid bacteria killing was verified through infectious keratitis animal model. The superior bactericidal effect of antibacterial materials could largely replace the bactericidal effect of the immune system. It is worth mentioning that this simultaneous sterilization and anti-inflammation treatment mode is a new exploration against the clinical treatment guidelines.

A Design of Electromagnetic Velocity Sensor with High Sensitivity Based on Dual-Magnet Structure.

The most permanent magnets in current electromagnetic velocity sensors are magnet cylinders that have been axially magnetized, with magnetic boots changing the propagation direction of the magnetic induction lines of the magnet cylinders. However, the magnetic field generated by the magnet cylinders is not fully utilized, which leads to uneven magnetic field intensity of the working air-gap and high magnetic field intensity of the nonworking air-gap. We propose a novel dual-magnet structure (DM) mainly consisting of two magnet loops that are magnetized radially and a magnetic conductive shaft, adopting a concentric nested configuration. The dual-magnet structure can make the magnetic induction lines enter the working air-gap directly from the magnet and increase the effective magnetic field, which is perpendicular to the coils in the working air-gap. This design can further improve the sensitivity of a velocity sensor and enhance its ability to detect weak signals in microtremor exploration. The validity of the dual-magnet structure has been established by numerical simulations and verified by experiments. The results reveal that the magnetic field intensity is increased by 29.18% and the sensitivity is improved by 23.9%, when the total volume and material of the magnet are unchanged. The full utilization of the material is achieved without increasing the complexity of the structure.