1.
FEBS Lett
; 368(2): 367-9, 1995 Jul 17.
Article
in English
| MEDLINE
| ID: mdl-7628639
ABSTRACT
Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress-induced changes in activity of mitochondrial monoamine oxidase type A (MAO-A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and serotonin content in comparison with native neuropeptide.
Subject(s)
Brain Chemistry/drug effects , Delta Sleep-Inducing Peptide/pharmacology , Hypoxia/enzymology , Monoamine Oxidase/metabolism , Amino Acid Sequence , Animals , Cytoplasm/enzymology , Delta Sleep-Inducing Peptide/analogs & derivatives , Delta Sleep-Inducing Peptide/chemical synthesis , Male , Mitochondria/enzymology , Molecular Sequence Data , Rats , Serotonin/analysis
2.
Vopr Med Khim
; 19(1): 3-5, 1973.
Article
in Russian
| MEDLINE
| ID: mdl-4150857