ABSTRACT
BACKGROUND AND OBJECTIVES: Brain death (BD) occurs in 9-24% of successfully resuscitated out-of-hospital cardiac arrests (OHCA). To predict BD after OHCA, we developed a novel brain death risk (BDR) score. METHODS: We identified independent predictors of BD after OHCA in a retrospective, single academic center cohort between 2011 and 2021. The BDR score ranges from 0 to 7 points and includes: non-shockable rhythm (1 point), drug overdose as etiology of arrest (1 point), evidence of grey-white differentiation loss or sulcal effacement on head computed tomography (CT) radiology report within 24 hours of arrest (2 points), Full-Outline-Of-UnResponsiveness (FOUR) score of 0 (2 points), FOUR score 1-5 (1 point), and age <45 years (1 point). We internally validated the BDR score using k-fold cross validation (k = 8) and externally validated the score at an independent academic center. The main outcome was BD. RESULTS: The development cohort included 362OHCA patients, of whom 18% (N = 58) experienced BD. Internal validation provided an area under the receiving operator characteristic curve (AUC) (95% CI) of 0.931 (0.905-0.957). In the validation cohort, 19.8% (N = 17) experienced BD. The AUC (95% CI) was 0.849 (0.765-0.933). In both cohorts, a BDR score >4 was the optimal cut off (sensitivity 0.903 and 0.882, specificity 0.830 and 0.652, in the development and validation cohorts respectively). DISCUSSION: The BDR score identifies those at highest risk for BD after OHCA. Our data suggest that a BDR score >4 is the optimal cut off.
Subject(s)
Cardiopulmonary Resuscitation , Out-of-Hospital Cardiac Arrest , Humans , Middle Aged , Out-of-Hospital Cardiac Arrest/etiology , Out-of-Hospital Cardiac Arrest/therapy , Brain Death , Retrospective Studies , Risk FactorsABSTRACT
Determining the meanings of words requires language learners to attend to what other people say. However, it behooves a young language learner to simultaneously encode relevant non-verbal cues, for example, by following the direction of their eye gaze. Sensitivity to cues such as eye gaze might be particularly important for bilingual infants, as they encounter less consistency between words and objects than monolingual infants, and do not always have access to the same word-learning heuristics (e.g., mutual exclusivity). In a preregistered study, we tested the hypothesis that bilingual experience would lead to a more pronounced ability to follow another's gaze. We used a gaze-following paradigm developed by Senju and Csibra (Current Biology, 18, 2008, 668) to test a total of 93 6- to 9-month-old and 229 12- to 15-month-old monolingual and bilingual infants, in 11 laboratories located in 8 countries. Monolingual and bilingual infants showed similar gaze-following abilities, and both groups showed age-related improvements in speed, accuracy, frequency, and duration of fixations to congruent objects. Unexpectedly, bilinguals tended to make more frequent fixations to on-screen objects, whether or not they were cued by the actor. These results suggest that gaze sensitivity is a fundamental aspect of development that is robust to variation in language exposure.
Subject(s)
Child Development/physiology , Eye Movements/physiology , Language Development , Multilingualism , Social Perception , Visual Perception/physiology , Eye-Tracking Technology , Female , Fixation, Ocular/physiology , Humans , Infant , MaleABSTRACT
BACKGROUND: Mortality from firearms among US schoolchildren is an increasingly major clinical and public health crisis. We explored temporal trends in mortality from firearms among US schoolchildren from 1999 to 2017 by age and race. METHODS: We used the Multiple Cause of Death Files of the United States National Center for Health Statistics; PubMed searches, and joinpoint regressions for trend analyses and calculated mortality rates and 95% confidence limits. RESULTS: From 1999 to 2017, the 38,942 deaths due to firearms in school-age children ranged from 340 per year at ages 5-14 to 2050 at 15-18 years. One epidemic among 5- to 14-year-olds began in 2009 and another among 15- to 18-year-olds began in 2014. The listed intents were 61% assault, 32% suicide, 5% accidental, and 2% undetermined. Blacks accounted for 41% of overall deaths, but only 17% of the school-age deaths. 86% of all deaths were boys. CONCLUSIONS: Mortality from firearms in US schoolchildren is increasing at alarming rates, especially among blacks and those aged 15-18 years. To the best of our knowledge, this is the first report to quantify these recent epidemics. Although federal laws prohibited them until recently, analytic studies designed a priori to do so are necessary to test the hypotheses generated by these descriptive data. We believe that combatting the epidemic of mortality from firearms among US schoolchildren without addressing firearms is analogous to combatting the epidemic of mortality from lung cancer from cigarettes without addressing cigarettes.
