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J Chemother ; 1(2): 80-3, 1989 Apr.
Article in English | MEDLINE | ID: mdl-2543801

ABSTRACT

The activity of ofloxacin was determined against 117 Enterobacteriaceae, 13 Acinetobacter var, anitratus, 124 Pseudomonas aeruginosa in comparison with other antibiotics. Its activity was very high: against Enterobacteriaceae the minimum inhibitory concentration (MIC)50 was 0.125 micrograms/ml, the MIC90 1 micrograms/ml, and the geometric mean (GM) was 0.4 micrograms/ml against Acinetobacter var. anitratus the MIC50 1 micrograms/ml, MIC90 4 micrograms/ml, GM 1.7 micrograms/ml. Unlike other authors we found that the activity of ofloxacin was influenced by the selection of P. aeruginosa resistant to carbenicillin and gentamicin.


Subject(s)
Gram-Negative Bacteria/drug effects , Ofloxacin/pharmacology , Quinolones/pharmacology , Acinetobacter/drug effects , Anti-Bacterial Agents/pharmacology , Enterobacteriaceae/drug effects , Microbial Sensitivity Tests , Pseudomonas aeruginosa/drug effects
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