Subject(s)
Kidney Neoplasms/diagnosis , Lipids/blood , N-Acetylneuraminic Acid , Sialic Acids/blood , Adult , Aged , Female , Humans , Kidney Neoplasms/blood , Lymphatic Metastasis , Male , Middle AgedABSTRACT
57 patients with disseminated tumors of various sites received 10 daily doses of 600 mg/m2 leakadin intravenously. The immunostimulating effect was observed (OKT4/OKT8 normalization). The data on leakadin pharmacokinetics are discussed.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Antineoplastic Agents/therapeutic use , Aziridines/therapeutic use , Azirines/therapeutic use , Neoplasms, Experimental/drug therapy , Neoplasms/drug therapy , Adjuvants, Immunologic/pharmacokinetics , Adult , Animals , Antineoplastic Agents/pharmacokinetics , Aziridines/pharmacokinetics , Humans , Killer Cells, Natural , Leukocyte Count , Mice , Middle Aged , Neoplasms/blood , Neoplasms, Experimental/blood , T-Lymphocytes, RegulatorySubject(s)
Interferon-gamma/administration & dosage , Adult , Breast Neoplasms , Drug Evaluation , Female , Humans , Injections, Intramuscular , Kidney Neoplasms , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Mesothelioma/drug therapy , Middle Aged , Pleural Neoplasms/drug therapy , Sarcoma/drug therapyABSTRACT
A case of spindle-cell carcinoma of the mammary gland in a young woman is described. The histology of the tumor was rather peculiar and characterized by the presence of two components: epithelial, consisting of polygonal polymorph cells with a trend to squamous-cell differentiation, and sarcoma-like, consisting of spindle-shaped cells. Transitional forms between cells of both components were found. At the ultrastructural level, cells of the epithelial and sarcoma-like components showed signs of their appurtenance to the squamous epithelium: crude bundles of tonofilaments in the cytoplasm combined with well-developed desmosomes between cells. The clinical course of the disease was characterized by a rapid progression, positive Abelev's test for alpha-phetoprotein, the lack of the tumor sensitivity to a broad spectrum of chemotherapy drugs.
